Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To evaluate the clinical and biological significance of
P-glycoprotein
(
P-gp
) expression in adult acute nonlymphocytic leukemia (ANLL),
P-gp
was detected in 169 patients including 152 previously untreated cases, 7 refractory cases, and 10 cases at remission by using monoclonal antibody UIC2 and flow cytometry.
P-gp
was expressed in 29% of previously untreated cases, being less than in 71% of the refractory cases.
P-gp
expression was not found in patients at remission. Morphologically,
P-gp
expression was high in hybrid acute leukemia (67%) and acute monoblastic leukemia (47%) subtypes. Immunologically,
P-gp
expression was significantly associated with CD34, CD7, CD14 or
CD42b
/CD61. Cytogenetically,
P-gp
expression was highly associated with poor prognosis abnormalities (54%), which was significantly higher than 7% of
P-gp
expression in good prognosis abnormalities. 23% of
P-gp
positive previously untreated ANLL (not including M3) achieved complete remission; this was significantly lower than 76% in
P-gp
negative cases. These suggested that
P-gp
expression is an index of poor prognosis in adult ANLL and
P-gp
positive ANLL has unique clinical and biological features.
...
PMID:[The clinical and biological significance of P-glycoprotein expression in acute nonlymphocytic leukemia]. 1037 70
