Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We studied the effects of ginsenosides and their metabolites on daunorubicin transport in multidrug-resistant
P-glycoprotein
(
P-gp
)-overexpressing KB-C2 cells.
Ginsenoside Rg1
, which is a protopanaxatriol-type ginseng saponin, did not have any effects on the accumulation of
P-gp
substrate daunorubicin. On the other hand, its metabolite M4, which has no sugar moiety, increased the accumulation 3.6-fold at 5 microM. Metabolites of protoanaxadiol-type saponin M1 and M12 also increased accumulation, but the effects were less than that of M4. The findings showed larger effects of metabolites without glucose moieties. Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human
P-gp
suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of
P-gp
.
...
PMID:Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells. 1791 77
