Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (
Tocophersolan
) is a polymeric synthetic version of vitamin E.
Tocophersolan
has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of
Tocophersolan
make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer,
P-glycoprotein
inhibitor and anticancer compound. For these reasons,
Tocophersolan
has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients.
Tocophersolan
has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of
Tocophersolan
with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.
...
PMID:Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications. 3252 72
