Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of multi-drug resistance (MDR1) and its product,
P-glycoprotein
(
P-gp
) on 5-aminolevulinic acid hexyl ester (Hexyl-
ALA
) mediated phototoxicity was determined with human uterine sarcoma cells, MES-SA control and MDR1 expressing MES-SA-Dx5. MDR1 expression reduced intracellular levels of the Hexyl-
ALA
metabolite, protoporphyrin IX (PpIX) to a limited degree and could be reversed with a
P-gp
inhibitor, verapamil.
P-gp
expression also reduced Hexyl-
ALA
photosensitivity. More importantly, photoactivated Hexyl-
ALA
reduced at the mRNA and protein levels without altering housekeeping GAPDH mRNA. These findings suggest that Hexyl-
ALA
could be used to selectively reduce
P-gp
expression in overcoming resistance to chemotherapy agents such as doxorubicin and paclitaxel.
...
PMID:Effects of photoactivated 5-aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells. 1862 94
