Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
ABC-type transport proteins, such as
P-glycoprotein
(
P-gp
), modify intracellular concentrations of many substrate compounds. They serve as functional barriers against entry of xenobiotics (e.g., in the gut or the blood-brain barrier) or contribute to drug excretion. Expression of transport proteins in the heart could be an important factor modifying cardiac concentrations of drugs known to be transported by
P-gp
(e.g., beta-blockers, cardiac glycosides, doxorubicin). We therefore investigated the expression and localization of
P-gp
in human heart. Samples from 15 human hearts (left ventricle; five non-failing, five dilated cardiomyopathy, and five
ischemic cardiomyopathy
) were analyzed for expression of
P-gp
using real-time RT-PCR, immunohistochemistry, and in situ hybridization. Immunohistochemistry revealed expression of
P-gp
in endothelium of both arterioles and capillaries of all heart samples. Although
P-gp
mRNA was detected in all samples, its expression level was significantly reduced in patients with dilated cardiomyopathy. We describe variable expression of
P-gp
in human heart and its localization in the endothelial wall. Thus, intracardiac concentrations of various compounds may be modified, depending on the individual
P-gp
level.
...
PMID:Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy. 1236 68
