Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Here we demonstrate that a ubiquitin E3-ligase,
FBXO21
, targets the multidrug resistance transporter, ABCB1, also known as
P-glycoprotein
(
P-gp
), for proteasomal degradation. We also show that the Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits
FBXO21
-directed degradation of
P-gp
. Thus, CD44 increases
P-gp
mediated drug resistance and represents a potential therapeutic target in
P-gp
-positive cells.
...
PMID:CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination. 2629 18
