Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Current treatment of high-grade osteosarcoma combines surgical removal of the lesion with chemotherapy. In this study we evaluated whether the expression of
P-glycoprotein
, a protein closely associated with multidrug resistance, may be helpful in identifying the patients whose tumours will be further resistant to specific agents. By using multidrug-resistant osteosarcoma cell lines as standards, the expression of
P-glycoprotein
was evaluated in 105 cases of primary and
metastatic osteosarcoma
by semiquantitative immunofluorescence. Overexpression of the protein was shown in 23% of primary and in 50% of metastatic lesions. In 38 cases, homogeneously treated and followed-up for at least 24 months, overexpression of
P-glycoprotein
appeared to be associated with a higher relapse rate and with a trend toward a worse outcome. These data support the role of
P-glycoprotein
in the response to chemotherapy and its involvement in the determination of the outcome of osteosarcoma patients.
...
PMID:Analysis of P-glycoprotein expression in osteosarcoma. 856 55
