Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic rhinosinusitis
is a common debilitating condition characterized by inflammation of the nose and paranasal sinuses. Osteitis is an associated finding but it is not clear whether it is cause or effect. This review will report on studies that have examined the role of osteitis in CRS, with the ultimate aim of clarifying the definition, pathogenesis and clinical implications of this relatively new clinical entity. Literature searches of Medline, EMBASE and CENTRAL using the search terms osteitis, rhinosinusitis, sinusitis, rhinitis, chronic disease, and recurrence were performed. 21 articles were identified and reviewed. The papers highlighted key pathological features including periosteal thickening, new woven bone formation, bone resorption, fibrosis and inflammatory cell infiltration. Radiological grading systems and basic science research into the role of matrix metalloproteinases and
P-glycoprotein
were also identified and reviewed.
...
PMID:Osteitis and chronic rhinosinusitis: a review of the current literature. 2652 84
Chronic rhinosinusitis
(
CRS
) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses. Besides being prevalent, the mechanisms involved in its pathogenesis are not clear and there are few therapeutic options with tolerable side effects.
P-glycoprotein
(
P-gp
) is an efflux pump responsible of extruding xenobiotics and cellular metabolites from multiple cell types. It has been widely studied in the cancer field, due to its ability to confer resistance to chemotherapy. It also promotes Type 2 helper T-cell polarizing cytokine secretion in
CRS
and may represent a potential target to differentiate subtypes of
CRS
and personalize treatment. This state-of-the-art review explores current knowledge on the participation of
P-gp
in the pathogenesis of
CRS
, the
P-gp
inhibition as a novel targeted therapeutic strategy and the exosomal
P-gp
test, a non-invasive biomarker that can represent an important advance in the field of rhinology.
...
PMID:P-glycoprotein and chronic rhinosinusitis. 3050 47
