Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We present a case of digoxin toxicity in the context of
dehydration
, renal dysfunction and concomitant use of the macrolide antibiotic, clarithromycin, which is known to inhibit
P-glycoprotein
-mediated efflux mechanisms of digoxin. A focused review of the literature is presented. Health care providers need to be vigilant of this mechanism of drug-drug interaction, which is also relevant to other commonly used cardiovascular drugs.
...
PMID:Digoxin toxicity precipitated by clarithromycin use: case presentation and concise review of the literature. 2190 34
