Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.14 (
ATP synthase
)
7,042
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A 66 kDa protein, denoted
P66
, not hitherto classified as an integral component of yeast
mitochondrial ATPase
, is often observed in preparations of this enzyme complex. A physical association exists between
P66
and the assembled ATPase complex since both components are coimmunoprecipitated by anti-F1 beta monoclonal antibody. Two recombinant clones expressing proteins immunologically similar to
P66
were isolated from a yeast genomic library in lambda gt11 by screening with a polyclonal anti-holo-ATPase antibody. Based on restriction site mapping and partial nucleotide sequence analysis, both clones encompass the gene encoding the yeast heat shock protein hsp60. The identification of
P66
with hsp60, taken together with its demonstrated association with the
mitochondrial ATPase
complex, is consistent with recent suggestions that hsp60 is involved in assembly of the
ATP synthase
complex.
...
PMID:Identification of a 66 KDa protein associated with yeast mitochondrial ATP synthase as heat shock protein hsp60. 214 85
