Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.3.14 (ATP synthase)
 7,042 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study addresses whether exercise during pregnancy in mouse alters mitochondrial function in the brains of the resultant offspring. We divided pregnant mice into four groups: a control group and groups of mice that exercised for 20 (E20m), 30 (E30m) and 40 min/d (E40m). The pregnant mice ran on a treadmill at 12 m/min, 5 d/week for a duration of 3 weeks. The protein expression of cytochrome c oxidase subunit Va (CVa) was downregulated in the offspring of the E20m group, unlike that in the control animals, whereas CVa expression was reserved in the E40m neonates. The F1-ATPase catalytic core (Core) protein expression levels were the highest in the E40m group neonates. Complex I, IV and ATPase activities were significantly lower in the E20m group than that in the control group neonates and were reserved in the E30m and E40m group neonates. The activities of citrate synthase and pyruvate dehydrogenase were consistent with those of complex I, IV and ATPase. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha, mitochondrial transcription factor A, nuclear respiratory factor-1 and mitochondrial DNA showed high levels of expression in the E40m neonates compared with the other groups. Malondialdehyde (MDA) levels in E40m neonates were higher than that in the controls but were lower than that in the E20m neonates. Finally, 40 min/d of maternal exercise improved mitochondrial function in the resultant pups and was concomitant with brain-derived trophic factor induction in the hippocampus, thereby functionally improving short-term memory.
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PMID:Maternal exercise during pregnancy affects mitochondrial enzymatic activity and biogenesis in offspring brain. 2322 20

Mondia whitei is an African traditional spice with aphrodisiac properties. Inhibition of mitochondrial permeability transition (mPT) pore is an important cytoprotective process essential for cell survival. In this study, the effects of methanol extract (ME), dichloromethane (DCMF), ethyl acetate (EF), and methanol fractions (MF) of Mondia whitei on mPT, mitochondrial ATPase, lipid peroxidation, testosterone hormone (TH), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were investigated; sperm analyses were also carried out. Male experimental rats were treated intraperitoneally with 25, 50, and 100 mg/kg bw of ME, DCMF, EF, and MF of Mondia whitei for two weeks. The positive and the negative controls received sildenafil citrate and the vehicle, respectively. The results showed that mPT was inhibited by MF at the highest dose. The ME, DCMF, and MF did not enhance ATPase activity. The levels of TH, FSH, and LH varied linearly with the drug dose only in EF. Malondialdehyde levels in the treated groups were significantly higher than the normal control. There were no significant defects in sperm produced by the animals in all the treated groups relative to the control. This study showed that the extract and fractions of Mondia whitei have cytoprotective effects and may prevent mitochondrial-mediated cell death.
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PMID:Mondia whitei, an African Spice Inhibits Mitochondrial Permeability Transition in Rat Liver. 3038 48