Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.14 (
ATP synthase
)
7,042
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Compartmentation is essential for the localization of biological processes within a eukaryotic cell.
ATP synthase
localizes to organelles such as mitochondria and chloroplasts. By contrast, little is known about the subcellular distribution of
CTP synthase
, the critical enzyme in the production of CTP, a high-energy molecule similar to ATP. Here I describe the identification of a novel intracellular structure containing
CTP synthase
, termed the cytoophidium, in Drosophila cells. I find that cytoophidia are present in all major cell types in the ovary and exist in a wide range of tissues such as brain, gut, trachea, testis, accessory gland, salivary gland and lymph gland. In addition, I find
CTP synthase
-containing cytoophidia in other fruit fly species. The observation of compartmentation of
CTP synthase
now permits a broad range of questions to be addressed concerning not only the structure and function of cytoophidia but also the organization and regulation of CTP synthesis.
...
PMID:Intracellular compartmentation of CTP synthase in Drosophila. 2051 29
