Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.14 (
ATP synthase
)
7,042
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A progressive dysfunction of the mitochondrion probably plays a decisive role in the aging process. In the present hypothesis it is suggested that the functional defect specifically concerns the catalytic subunit of the mitochondrial
F1-ATPase
. This proposal is based on observations concerning two classical models of the aging process. 1. The
Werner syndrome
of premature aging is autosomally recessive; meaning that this disorder--in analogy with other recessive inborn errors of metabolism--results from a single specific mutation, typically resulting in an enzyme defect. 2. The strong association between the ATPase activity of the SV40 T-antigen and the process of cellular immortalization in vitro, suggests that the putative enzyme dysfunction could concern an ATPase. The decrease with aging in the activity of the mitochondrial
F1-ATPase
--the main producer of ATP--could lay behind the progressive lack of homeostasis observed in senescence.
...
PMID:The mitochondrial F1-ATPase and the aging process. 793 87
