Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.3.14 (ATP synthase)
 7,042 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this paper, an extension of the Hodgkin-Huxley model has been presented to describe the interaction between the nerve fibres. Based on the equivalent electrical circuit, the conductance per unit area between two coupled axons has been introduced as the pairwise coupling factors. Based on the measurement of the membrane potential, these coupling factors can be estimated by linearised identification methods. Therefore, the axon-to-axon interaction can be characterized, which improves the accuracy of the models. Comparing with the simulation studies of the mechanistic model, the presented model is more convenient to be analyzed while the computational complexity has been reduced. Using the presented description, the simulation results indicate that the presented model and the analysis strategy are effective.
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PMID:A model study of the neural interaction via mutual coupling factor identification. 2906 Jun 10

Gravitational forces can impose physical stresses on the human body as it functions to maintain homeostasis. It has been reported that astronauts exposed to microgravity experience altered biological functions and many subsequent studies on the effects of microgravity have therefore been conducted. However, the anticancer mechanisms of simulated microgravity remain unclear. We previously showed that the proliferation of human Hodgkin's lymphoma (HL) cells was inhibited when these cells were cultured in time-averaged simulated microgravity (taSMG). In the present study, we investigated whether taSMG produced an anticancer effect. Exposure of human HL cells to taSMG for 2 days increased their reactive oxygen species (ROS) production and NADPH oxidase family gene expression, while mitochondrial mass, ATPase, ATP synthase, and intracellular ATP levels were decreased. Furthermore, human HL cells exposed to taSMG underwent autophagy via AMPK/Akt/mTOR and MAPK pathway modulation; such autophagy was inhibited by the ROS scavenger N-acetylcysteine (NAC). These results suggest an innovative therapeutic approach to HL that is markedly different from conventional chemotherapy and radiotherapy.
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PMID:Microgravity induces autophagy via mitochondrial dysfunction in human Hodgkin's lymphoma cells. 3027 24