Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.1 (
Mg2+-ATPase
)
1,484
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Maintaining lipid membrane integrity is an essential aspect of plant tolerance to high temperature. P
4
-type ATPases are responsible for flipping and stabilizing asymmetric phospholipids in membrane systems, though their functions in stress tolerance are not entirely clear. Aminophospholipid
ATPase6
(ALA6) is a member of the P
4
-type ATPase family, which has 12 members in
Arabidopsis thaliana
. Here, we show that a loss-of-function mutant of ALA6 (
ala6
) exhibits clear sensitivity to heat stress, including both basal and acquired thermotolerance treatments. Overexpression of
ALA6
improves seedling resistance to heat stress, while mutated
ALA6
transgenic plants, in which the conserved functional site of the ALA family has a point mutation, are still susceptible to heat stress like
ala6
loss-of-function mutant. In addition,
ala6
displays higher ion-leakage during heat treatment, suggesting that the lipid
flippase
activity of ALA6 plays a vital role in heat stress responses. Transcriptome analysis reveals differences in gene expression between
ala6
and wild-type plants with or without heat stress. The differentially expressed genes are involved primarily in the physiological processes of stress response, cellular compartment maintenance, macromolecule stability and energy production. Our results suggest that ALA6 is crucial for the stability of membrane when plants suffer from high temperature stress.
...
PMID:ALA6, a P
4
-type ATPase, Is Involved in Heat Stress Responses in
Arabidopsis thaliana
. 2904 90
