Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.3.1 (Mg2+-ATPase)
 1,484 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By decreasing water salinity gradually, the Pampus argenteus juveniles were cultured at water salinity 25, 20, 15 and 10, for 24 h, 48 h, 96 h and 120 h, respectively, with the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR) in liver and the activities of Na+/K+- and Ga2+/Mg2+ -ATPase in gill and kidney determined. With the lowering of water salinity and the elongation of treated time, the liver SOD and GST activities had a trend of decreasing after an initial increase (P < 0.05), while the CAT activity was lower than the control except that it had a slight increase at salinity 20 cultured for 24 h and at salinity 15 cultured for 48 h (P < 0.05). The liver GPX activity had an increasing trend (P < 0.05), while the GR activity at salinity 15 cultured for 24 h increased first and then fell down to a relatively low level (P < 0.05). The Na+/K+ - and Ga2+/Mg2+-ATPase activities in the gill and kidney also decreased after an initial increase (P < 0.05), only the increase of ATPase activity at the thresholds of water salinity and treated time differed between the two organs. The results indicated that the decrease of water salinity could effectively stimulate and enhance the antioxidant enzyme activities in juvenile P. argenteus liver and the ATPase activities in its gill and kidney, and thereby, could effectively eliminate the excessive reactive oxygen species (ROS), sustain the intracellular homeostasis, and minimize the body damage. However, characterized by certain specificity and time sequentiality, the activation of test enzymes could also be inhibited when the salinity varied beyond the tolerance range of the body.
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PMID:[Effects of low salinity stress on the antioxidant enzyme activities in juvenile Pampus argenteus liver and the APTase activities in its gill and kidney]. 2177 33

Brief episodes of myocardial ischemia-reperfusion (IR) employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of ischemic postconditioning on an ischemic reperfusion (IR)-induced myocardium oxidative injury in rat model. Results showed that ischemic postconditioning could improve arrhythmia cordis, reduce myocardium infarction and serum creatin kinase (CK), lactate dehydrogenase (LDH) and aspartate transaminase (AST) activities in IR rats. In addition, ischemic postconditioning could still decrease myocardium malondialdehyde (MDA) level, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) activities. It can be concluded that ischemic postconditioning possesses strong protective effects against ischemia reperfusion-induced myocardium oxidative injury in IR rats.
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PMID:Protective effect of ischemic postconditioning against ischemia reperfusion-induced myocardium oxidative injury in IR rats. 2245 31