Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.6.3.1 (Mg2+-ATPase)
 1,484 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An investigation of the mechanism of development of hepatic encephalopathy induced by CCl4 was performed in rats. CCl4 (1.0 ml/kg three times per week for over 10 weeks) caused hepatic encephalopathy in 80% of the treated rats. Accompanying the hepatic encephalopathy were hematemesis, abdominal dropsy, and hyperammonemia, conditions observed in hepatic coma patients. The blood ammonia levels were tremendously increased in only those rats with hepatic encephalopathy. Hepatic activities of carbamylphosphate synthetase (CPS) and argininosuccinate synthetase (ASS), important enzymes of the urea cycle, were significantly inhibited by CCl4. However, the causality between the inhibition of CPS or ASS activity and the increase in blood ammonia levels was not observed. On the other hand, the content of ATP, which is a substrate of CPS and ASS, was decreased by 60% in liver of rats with hepatic encephalopathy. The activity of Mg2+-ATPase which can decompose hepatic ATP was increased by 60 and 300% in mitochondria and microsomes, respectively, of livers of rats with CCl4-induced encephalopathy. There was a good correlation between the decreased hepatic ATP content and the increased mitochondrial Mg2+-ATPase activity. Furthermore, there was also a good correlation between the increase in blood ammonia levels and the increase in Mg2+-ATPase activity in microsomes. These findings suggest that hyperammonemia, which was produced by the decrease in hepatic content and by the inhibition of CPS and ASS, may play an important role in induction of hepatic encephalopathy.
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PMID:Blood ammonia levels and hepatic encephalopathy induced by CCl4 in rats. 296 38

CCl4 is an industrial agent with known toxic effects on the environment. There are so many studies about hepatotoxic effects of CCl4. We herein studied the effects of CCl4 on Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities on erythrocyte membranes and trace element levels of serum erythrocyte and liver tissue of rats. Study was performed on control group (group C, n=8) and a study group (group S, n=8) in which CCl4 was given. Na+/K+-ATPase and Ca2+/Mg2+-ATPase were significantly reduced in CCl4-treated group (p<0.01, p<0.001). Trace element levels also showed statistically significant differences in CCl4-treated group. Membrane Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities were diminished due to CCl4-induced injury on erythrocyte membranes. CCl4 also changed the trace element levels of serum erythrocyte membrane and liver by altering the mineral substance concentrations.
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PMID:The effects of CCl4 on Na+/K+-ATPase and trace elements in rats. 1943 57