Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.1 (
Mg2+-ATPase
)
1,484
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of different
a-D-Glucose
(Glu) concentrations (0-16 mM) on Na+, K+-ATPase and
Mg2+-ATPase
activities were investigated in homogenates of adult male rat whole brain at 37 degrees C. The enzyme activities were determined after 1 h preincubation with Glu. Brain Na+, K+-ATPase was not affected by Glu different concentrations. On the contrary,
Mg2+-ATPase
activity was considerably reduced with Glu concentrations lower than 4 mM. The enzyme was inhibited 40%, 50% or 80% with 3, 2 or 1 mM of Glu, respectively. The above results suggest: a) The various concentrations of Glu have no effect on brain Na+, K+-ATPase activity. b) The inhibited brain
Mg2+-ATPase
in hypoglycemia produces low intracellular Mg2+, which could modulate the activity of Mg2+-dependent enzymes and the rates of protein synthesis and growth of the cell.
...
PMID:Reduced Mg2+-ATPase activity in the hypoglycemic adult rat brain. 1172 6
