Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: EC:3.6.3.1 (
Mg2+-ATPase
)
1,484
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Noradrenaline
(NA) and isopropyladrenaline in a dose of 11 microM/kg were shown to activate in vivo Na+, K+-ATPase and
Mg2+-ATPase
in the mouse renal microsomal fraction. NA (10(-6) M) increased the activity of Na+, K+-ATPase in vitro and did not affect the activity of
Mg2+-ATPase
in the hepatic and renal microsomal fractions. NA did not significantly affect in vivo the mitochondrial ATPases activity in the presence of various stimulators (Mg, dinitrophenol, bicarbonate) and inhibitors (oligomycin, bicyclohexyl carbodiimide) in the mouse liver and kidneys. cAMP (10(-6) M) activated Na+, K+-ATPase in vitro reduced the activity of
Mg2+-ATPase
in the microsomal fraction, and did not change the activity of the mitochondrial ATPases in the mouse liver and kidneys. The following scheme of the mechanism of catecholamine (CA) effect on Na+, K+-ATPase is suggested: CA leads to beta-adrenoreceptors leads to adenylate cyclase leads to cAMP leads to protein kinase leads to Na+, K+-ATPase. The mechanism of
Mg2+-ATPase
regulation is discussed.
...
PMID:[Catecholamine regulation of the liver and kidney ATPase activity in mice]. 627 63
