Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.1 (
Mg2+-ATPase
)
1,484
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of repeated intraperitoneal administration of
aflatoxin B1
on the peripheral and central nervous systems of rats were investigated. Biochemical markers of neurotoxicity were monitored in nervous tissues following
aflatoxin B1
dosage and after the cessation of
aflatoxin B1
administration.
Aflatoxin B1
increased the activities of beta-glucuronidase and beta-galactosidase in the central and peripheral nervous systems. Repeated exposure of rats to
aflatoxin B1
also activated Na+ K+-ATPase and inhibited
Mg2+-ATPase
. Nervous tissue levels of DNA and total protein increased while the concentrations of RNA and phospholipid were depressed by
aflatoxin B1
. The alterations in these parameters were specific for each of the tissues examined during the recovery of the rats. The findings indicate that the repeated administration of
aflatoxin B1
to rats results in degeneration in the central and peripheral nervous systems that may be related to the overt toxicity observed following aflatoxin administration.
...
PMID:The neurotoxicity of aflatoxin B1 in the rat. 613 86
