Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.6.3.1 (Mg2+-ATPase)
 1,484 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This investigation was undertaken to study the effects of prolactin and bromocriptine on the testis of the musk shrew. None of these treatments had any effect on the weight of testis or on the accessory sex organs. Treatment of prolactin or bromocriptine failed to induce any change in esterified and free cholesterol content of the testis. No significant alterations were also recorded in the levels of macromolecules and in the levels of enzymes of the testis and the prostate gland. On the other hand, bromocriptine treatment resulted in an increase in the activity of Mg2+-ATPase and phospholipid:DNA ratio of the testis with a concomitant decrease in its DNA content. The absence of any change in the content of fructose in the ampullary gland, in the activity of beta-glucuronidase of the kidney, in cholesterol content of the testis, in diameters of seminiferous tubule and Leydig cell nucleus, in activities of acid phosphatase and beta-glucuronidase of the testis and in the weight of accessory sex organs of prolactin and bromocriptine treated musk shrews suggests that prolactin does not play a significant role in regulating the testicular function of the musk shrew.
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PMID:Effects of prolactin and bromocriptine on physiological status of testis of the musk shrew (Suncus murinus L.). 297 86

The effects of repeated intraperitoneal administration of aflatoxin B1 on the peripheral and central nervous systems of rats were investigated. Biochemical markers of neurotoxicity were monitored in nervous tissues following aflatoxin B1 dosage and after the cessation of aflatoxin B1 administration. Aflatoxin B1 increased the activities of beta-glucuronidase and beta-galactosidase in the central and peripheral nervous systems. Repeated exposure of rats to aflatoxin B1 also activated Na+ K+-ATPase and inhibited Mg2+-ATPase. Nervous tissue levels of DNA and total protein increased while the concentrations of RNA and phospholipid were depressed by aflatoxin B1. The alterations in these parameters were specific for each of the tissues examined during the recovery of the rats. The findings indicate that the repeated administration of aflatoxin B1 to rats results in degeneration in the central and peripheral nervous systems that may be related to the overt toxicity observed following aflatoxin administration.
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PMID:The neurotoxicity of aflatoxin B1 in the rat. 613 86

Altered membrane integrity has been suggested as a major factor in the development of cellular injury during myocardial necrosis. The present study was designed to investigate the effect of diosgenin on lysosomal hydrolases, membrane-bound enzymes, and electrolytes during isoproterenol (ISO)-induced myocardial necrosis in rats. Animals were pretreated with DIOS (80 mg/kg) for a period of 35 days. Myocardial infarction was experimentally induced with ISO (85 mg/kg) twice at 24 h interval. Experimental myocardial infarction was evidenced with marked elevation of creatine kinase-MB (CK-MB) in serum with concomitant increase in lipid peroxidation (plasma thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP)). Activity of lysosomal hydrolases (beta-glucuronidase, beta-N-acetyl glucosaminidase, beta-D-galactosidase, cathepsin D, and acid phosphatase) was found to be increased in serum and heart tissue of ISO-alone treated animals. DIOS (80 mg/kg) pretreated groups showed significant decrease in CK-MB, lipid peroxidation, and lysosomal hydrolases activity. The membrane-bound enzymes such as Ca2+-ATPase and Mg2+-ATPase activity was increased and Na+/K+-ATPase activity was decreased in the heart tissues of ISO-alone treated animals. These enzyme alterations lead to the change in the electrolytes content such as sodium, potassium, and calcium in the heart tissue. However, DIOS (80 mg/kg) pretreatment reversed the membrane-bound enzymes activity and thereby maintained the normal electrolyte concentration. These results suggest the protective action of diosgenin in ISO-induced myocardial infarction. The salubrious effect observed in this study might be due to the antioxidant and membrane stabilizing potential of diosgenin.
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PMID:Antilipoperoxidative and membrane stabilizing effect of diosgenin, in experimentally induced myocardial infarction. 1923 76