Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.1 (
Mg2+-ATPase
)
1,484
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of
Mg2+-ATPase
was determined in the cortex mitochondrial fraction, limbic system and medulla oblongata under conditions of chronic stress as well as against a background of preliminary therapy by psychotropic drugs. At the
inanition
stage of animals the chronic stress is shown to inhibit sharply the process of respiration and phosphorylation (by dissociation) and to decrease the content of brain macroergs. The activity of
Mg2+-ATPase
in the mitochondrial fractions is lowered. It practically restores to the control level against a background of stress with preliminary course of administering nicotinic acid and GABA derivatives (lithonite, nicogamol and phenibut) to rats in average therapeutic doses. Mebicar, meprobamate and chlorodiazepoxide produce a less pronounced normalizing effect on the activity under study. It is substantiated to be expedient to apply psychotropic drugs as stress-protectors for normalization of energy metabolism of brain neurons.
...
PMID:[Mg2+-ATPase activity of brain mitochondria fractions in chronic stress and its correction by psychotropic agents]. 615 Dec 70
