Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.3.1 (Mg2+-ATPase)
 1,484 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The interfascicular oligodendroglia of the rat striatum nucleus is studied in control animals and under experimentally induced brain edemas. Enzyme histochemical studies were performed. Normal oligodendrocytes show two different enzymatic distributions. While Mg2+-ATPase, TPPase, TPPase, adenylate cyclase and SDH are shown to be situated at the cell bodies and some proximal processes, 5'-nucleotidase reaction is seen at the cell fine distal processes. In spite of its trong activity in oligodendroglial endings the latter enzyme is not seen at the myelin sheath. This sheath and the interfascicular cells being intimately related, 5'-nucleotidase appears to be important not only during myelination, as almost all authors emphasize, but also in the adult myelin metabolism. Experimental brain edema shows some changes in the interfasicular oligodendroglia enzymatic activites for 5'-nucleotidase, Mg2+-ATPase and adenylate cyclase. A progressive disappearance of the former enzyme is observed. These features and those of derived from local ionic alterations may be concerned with the special susceptibility of white matter for some types of brain swellings.
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PMID:Enzyme histochemistry of rat interfascicular oligodendroglia, with special reference to 5'-nucleotidase. 101 43