Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.1 (
Mg2+-ATPase
)
1,484
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kinetic parameters of the inhibitory effect of vincristine on Mg2+ATPase activity containing in the actomyosin-like protein from rat
sarcoma
45 and in actomyosin from rat skeletal muscle was studied. The alkaloid decreased the VM value for the reaction catalyzed by ATPase in presence of Mg2+ and EGTA and did not alter Km value for both contractile proteins. Inhibitory constants, calculated for the actomyosin from skeletal muscles and for the actomyosin-like protein from
sarcoma
45, constituted 520 mcM and 250 mcM, respectively. Vincristine appears to inhibit
Mg2+-ATPase
containing in these contractile proteins studied by the non-competitive type, simultaneously with lowering of the activating effect of actin on the myosin-derived ATPase.
...
PMID:[Effect of vincristine on Mg2+-ATPase activity of actomyosin-like protein from sarcoma-45 and actomyosin from rat skeletal muscle]. 252 43
