Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.1.3 (
ATPase
)
65,361
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
5,6,7,8-tetrahydrocarbzzole-3-acetic acid (
AH 2835
) given to maternal rats throughout their gestation produces an experimental model of the autosomally inherited human infantile polycystic disease Potter type I in the rat foetuses. The affected animals have cystic lesions in their kidneys, liver and pancreas like those seen in the human. Evidence is presented for the aetiology of the experimental lesion being related to the action of
AH 2835
on the specific activity of the ouabain sensitive (Na+ + K+)-
ATPase
of absorptive epithelia. It is noted that two cystic kidney diseases, the ocngenital nephrotic syndrome and infantile polycystic disease Potter type I are both inherited as autosomal recessive traits and are therefore likely to be caused by enzyme abnormalities, and that the compound
AH 2835
can be used to produce experimental models of both of these diseases.
...
PMID:Polycystic disease of kidney, liver and pancreas; a possible patholgenesis. 13 39
