Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The effects of dextrose, magnesium (Mg) and adenosine on membrane potential and force of contraction were studied in driven and overdriven canine cardiac Purkinje tissue. 2. Dextrose (50 mmol/L) and adenosine (4-6 mmol/L) both showed protective action (the latter to a lesser extent) against simulated anoxia and reperfusion-induced arrhythmias, increased force of contraction transiently on reperfusion, and the former sustained the increase in force to a lower level as long as it was in the superfusing solution. 3. Dextrose (50 mmol/L) and Mg (5 mmol/L) restored overdrive-induced hyperpolarization during simulated anoxia. Adenosine was largely ineffective. 4. It was concluded that dextrose and adenosine (to a lesser extent) protect against arrhythmias by replenishing the critical intracellular pool of ATP which controls membrane transport of electrolytes such as K and Ca. Restoration of Na-K ATPase activity alone (as in the case of high Mg concentrations) is not sufficient to prevent arrhythmias.
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PMID:Dextrose-, adenosine- and magnesium-induced protective actions during anoxia and reperfusion in canine Purkinje tissue. 781 22

The present study was undertaken to evaluate the antiseizure activity spectrum of insulin against various behavioral seizure models in rats. Insulin was injected intraperitoneally (i.p.) at a test dose of 1 U/kg. Dextrose (3 g/kg) was administered simultaneously with insulin to counteract its hypoglycemic effect and induce a normoglycemic state. Insulin was found to significantly decrease the incidence, intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by pentylenetetrazole (60 mg/kg i.p.) and significantly decrease the intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by penicillin (2000 U/intracerebrocortical). Insulin was not only found to prolong the latency of all the seizure components but was found to reduce the incidence of focal myoclonic twitches and generalized tonic-clonic convulsions induced by kainic acid (12 mg/kg i.p.) as well. Insulin was shown to be ineffective to suppress ouabain (5 micrograms/intracerebroventricular) induced seizures. These findings indicate that insulin possesses a broad spectrum of antiseizure activity in rats. Interaction with brain Na(+)-K(+)-ATPase has been discussed as a possible mechanism of action.
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PMID:Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats. 895 15