Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.1.3 (
ATPase
)
65,361
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A decrease in activity of Ca2(+)-
ATPase
and activation of Na+, K(+)-
ATPase
, correlating with elevation in content of phosphatidyl inositol and phosphatidyl serine, were detected in erythrocyte membranes of patients with the infectional-allergic form of bronchial asthma. Microviscosity of the erythrocyte membranes, estimated by fluorescence spectra of pyrene, was not altered, while negative charge as shown by ANS- fluorescence, was slightly increased on the membrane surface.
Euphylline
, intal, levamizole and glucocorticosteroid were found to regulate the ATPases activity in vivo and in vitro.
...
PMID:[Structural-functional properties of erythrocyte membranes in patients with infectious-allergic bronchial asthma]. 253 46
The antiplasmodial active extract of
Xanthium
cavanillesii contains 3,4-dicaffeoyl quinic acid (3,4-DCQA), 3,5-dicaffeoyl quinic acid (3,5-DCQA) and 1,3,5-tricaffeoyl quinic acid (1,3,5-TCQA). These results inspired us to investigate the interaction of these molecules with a promising validated target of Plasmodium, PfATP6 orthologue of mammalian Ca
+2
-
ATPase
. Models of this receptor were obtained through comparative modelling. Afterwards, molecular docking studies were used to identify possible interaction modes of these caffeoyl quinic derivatives on the binding site. The 1,3,5-TCQA had the best energy, but all of these had better energy than thapsigargin, a non-competitive inhibitor of the sarco/endoplasmatic reticulum Ca
+2
-
ATPase
(SERCA).
...
PMID:Caffeoylquinic acids from antiplasmodial active extract of Xanthium cavanillesii fruits and their molecular modelling studies. 2768 50
