Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Orally administered cadmium has been known to cause diarrhea and flatulence of the gastrointestinal tract. Scanning electron microscopic observations revealed that the absorptive cells on the tip of the intestinal villi were affected to some extent by administration of 2.5 microgram CdSO4/10 g of body weight (b. w.). Administration of higher doses of CdSO4 made the microvilli of the absorptive cells sparse and caused degeneration of the cells. Strong enzymic activities of alkaline phosphatase, acid phosphatase, magnesium-dependent ATPase, and sodium-potassium-dependent ATPase were recognized at the microvilli of the absorptive cells of the villi in the control mice. The enzymic activities of magnesium-dependent ATPase and sodium-potassium-dependent ATPase became weak with increasing dosages of CdSO4. The microvilli of the absorptive cells showed a strong alkaline phosphatase activity at a dose less than 25 microgram CdSO4/10 g of b. w., while some inhibitory effects could be recognized with 50 microgram/10 g of b. w. After administration of 2.5 microgram CdSO4/10 g of b. w., no acid phosphatase reaction products were found only at the absorptive cells located on the tip of the villi. Administration of a large quantity more than 5 microgram/10 g of b. w. strongly affected the acid phosphatase activity. It may be possible that the digestive functions are impaired by low cadmium administration.
 ...
PMID:Scanning electron microscopic and enzyme histochemical observations on the cadmium-affected gastrointestinal villi of mice. 645 14

Anise (Pimpinella anisum) has been used as a traditional aromatic herb in many drinks and baked foods because of the presence of volatile oils in its fruits commonly known as seeds. Hot water extracts of the seeds have been used also in folk medicine for their diuretic and laxative effect, expectorant and anti-spasmodic action, and their ability to ease intestinal colic and flatulence. The aim of this work was to study the effect of aniseed oil on transport processes through intestinal and renal epithelia and determine its mechanism of action. The essential oils were extracted from the seeds by hydrodistillation and analyzed by gas chromatography. Aniseed oil enhanced significantly glucose absorption from the rat jejunum and increased the Na+-K+ ATPase activity in a jejunal homogenate in a dose dependent manner. The oil, however, exerted no effect on water absorption from the colon and did not alter the activity of the colonic Na+-K+ ATPase. When added to drinking water, it reduced the volume of urine produced in the rat and increased the activity of the renal Na+-K+ ATPase even at extremely low concentrations. It was concluded that aniseed oil increases glucose absorption by increasing the activity of the Na+-K+ ATPase and consequently the sodium gradient needed for the sugar transport. Its anti-diuretic effect is also mediated through a similar mechanism in the kidney whereby a stimulation of the Na+-K+ pump increases tubular sodium reabsorption and osmotic water movement. The colonic Na+-K+ ATPase was however, resistant to the oil.
 ...
PMID:Aniseed oil increases glucose absorption and reduces urine output in the rat. 1462 36