Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ion transport properties and some components of lipid structure in myocardial sarcolemma were studied under conditions of short-term acute ischemia simulated in rabbits by means of intravenous administration of vasopressin at a dose of 0.2 U/kg. The acute coronary insufficiency was accompanied by distinct alterations in the parameters specific for calcium metabolism and transport: activity of Na+, K+-ATPase and the rate of Na+Ca2+ turnover were decreased, while 45Ca-binding ability and content of Ca2+ were increased in the myocardial sarcolemma. Alterations in lipid structure, phospholipid composition of membranes and accumulation of free fatty acids appear to be responsible for the phenomenon observed. The increased rate of calcium ions transport found may occur due to alterations in the sarcolemma structure.
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PMID:[Ion-transport system and various components of sarcolemma structure during acute myocardial ischemia]. 357 53

In closed-chest dogs, 30, 50 and 70% restriction of coronary blood flow was carried out by catheterization and autoperfusion of the circumflex branch of the left coronary artery. At 70% restriction, a mild decrease in most contractility indices was observed, without simultaneous impairment of the indices of systemic haemodynamics. Changes in energy metabolism appeared already in the initial stage of coronary insufficiency. A characteristic features at suppression of aerobic oxidation was an increase of the cAMP level of glycolytic activity of the pentoso-phosphate cycle, which ensured a sufficiently high ATP level in the myocardium. A limiting factor were disturbances in the system of energy transport (creatine phosphate, creatine phosphokinase) and of the calcium pump (Ca++-ATPase of the sarcoplasmic reticulum, SPR), which evidently led to a decrease of the inotropic properties of the myocardium at 70% restriction of coronary blood flow. Signs were found of structural lesions of the myofibrils and the SPR.
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PMID:Contractile function, energy metabolism and myocardial structure at graded restriction of coronary blood flow. 717 90