Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Morphologic as well as biochemical alterations in chronic ischemic myocardial tissue without infarction were studied in dogs utilizing the Ameroid constrictor. 2. Serum creatine kinase activity elevated at around three weeks after placing the Ameroid constrictor around the circumflex branch of the left coronary artery suggestive of myocardial tissue injury followed by the initial activation caused by surgery. 3. Subendocardial proliferation of connective tissue was observed in about 60% of the experiments, but the middle and the subepicardial muscles were morphologically intact. 4. The marked increase in glycogen particles was observed in the subendocardial muscle cells in most of the experiments, and mild features of myocardial cellular necrosis were found in approximately 60% of the experiments. 5. ATPase activities of the structural proteins as well as sarcoplasmic reticulum in the ischemic myocardium shoed relatively higher values than those in the non-ischemic myocardium. However, no substructural changes were observed in SDS gel electrophoresis in both the fractions. 6. The alterations in the chronic myocardial ischemia are supposed to be essentially the same as those in myocardial necrosis followed by acute coronary occlusion.
 ...
PMID:Morphologic and biochemical studies on the experimental chronic ischemic myocardium with the Ameroid constrictor. 14 55

The study was performed in 25 kidneys of people who died from mechanic asphyxia and craniocerebral trauma and in 56 of those who died from cardiovascular diseases (hypertensive disease, chronic ischemic heart disease and their combination) with the use of histochemic, morphometric and variational statistic methods. It was established that in cardiovascular diseases studied ATPase and alkaline phosphatase activity increased in vessels mainly in juxtamedullary zone of the kidneys substantia alba. The enzymatic activity changes studied are obviously connected with the functional load increase at this zone of kidneys and the juxtaglomerular shunt reinforcement. This process can be regarded as the display of compensatory adaptive reactions morphochemical equivalent.
 ...
PMID:[Enzymatic activity of arterial vessels of the human kidney in the norm and various cardiovascular diseases]. 1155 19