Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because they are easily accessible and because their secretion can be obtained in an almost pure form, the salivary glands are an adequate model for the study of hydroelectrolytic secretion of secreting epithelia which cannot generate an action potential. It is generally accepted that the salivary secretion occurs in two stages: in the acini, where primary saliva is formed similar in ionic constituents to plasmatic water, and in the ducts of the adenomer, where such original saliva is modified by absorption and secretion of electrolytes. Departing from Thaysen's hypothesis, the mechanisms responsible for the preparation of final saliva are reviewed. The authors briefly discuss the evolution of the ideas about salivary secretion emphasizing recent works which modified early theories, particularly the role of the Na-K ATPase and the cotransportation of the Cl- ion. Ideas about what occurs along the ducts are also reviewed, starting with the hypothesis of Brusilow and Cook, which was later on gradually modified. Recent works are compared to those of the authors. Certain topics, such as the impermeability of duct walls to water, existence of a threshold for the transport of Na+, possibility of experimentally obtaining saliva with higher osmotic pressure than plasma are stressed. Finally, the role of loop diuretics which interfere in potassium transport channels is discussed.
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PMID:[Electrolyte secretion in saliva]. 172 79

Whereas the effectivity of H2O2 can be influenced only little through the acidulation (to pH 2.7) its combination with chinosole are distinctly superior to H2O2 in their effectivity. The most increase of effectivity is attainable with the admixture of anionic and cationic detegents. Ideas about different character of effectivity of combinations partner were discussed by reason of the influence of ATPase activity and optical dencity of E. coli cells.
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PMID:[Antibacterial mechanism of action of hydrogen peroxide preparations]. 213 72