Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.1.3 (
ATPase
)
65,361
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Calcium signaling can elicit different pathways involved in an extreme variety of biological processes. Calcium levels must be tightly regulated in a spatial and temporal manner in order to be efficiently and properly utilized in the host physiology. The Ca
2+
-
ATPase
, encoded by
pmr-1
gene, was first identified in yeast and localized to the Golgi and it appears to be involved in calcium homeostasis. PMR-1 function is evolutionary conserved from yeast to human, where mutations in the orthologous gene ATP2C1 cause Hailey-Hailey disease. In this work, we used the
Caenorhabditis elegans
model system to gain insight into the downstream response elicited by the loss of
pmr-1
gene. We found that
pmr-1
knocked down animals not only showed defects in the oligosaccharide structure of glycoproteins at the cell surface but also were characterized by reduced susceptibility to bacterial infection. Although increased resistance to the infection might be related to lack of regular recognition of
C. elegans
surface glycoproteins by microbial agents, we provide genetic evidence that
pmr-1
interfered nematodes mounted a stronger innate immune response to
Gram-positive bacterial infection
. Thus, our observations indicate
pmr-1
as a candidate gene implicated in mediating the worm's innate immune response.
...
PMID:
Pmr-1
gene affects susceptibility of
Caenorhabditis elegans
to
Staphylococcus aureus
infection through glycosylation and stress response pathways' alterations. 3177 13
