Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vitamin A deficiency modifies Na and K concentration values in oedematous testes. On one hand there is an increase of Na, on the other hand a decrease of K. Subcellular protein concentrations are impaired. Testicular fluid electrophoresis show it gets from plasma or lymph. No significant influence of ATPase (Na,+ K+) was demonstrable. Stimulation of lysosomal beta-glucuronidase can explain this fluid accumulation.
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PMID:[Biochemical aspects of testicular degeneration in the vitamin A deficient rat. 4. Permeability of the vascular walls]. 13 76

The effect of vitamin A deficiency on the intestinal absorption of nutrients and the activities of brush border enzymes were studied in albino rats. Intestinal uptakes of D-glucose, L-methionine, L-tryptophan and L-histidine were significantly greater in vitamin A-deficient animals than in controls. The specific activities of total adenosine triphosphatase (ATPase), ouabain-sensitive ATPase, maltase and sucrase in the intestinal mucosa of vitamin A-deprived rats were 121, 124, 131 and 134 per cent respectively, of the corresponding values in control animals. The DNA content of the small intestine in vitamin A-deficient rats was 36.5 per cent lower than in control rats. The stimulation in digestive and absorptive capacity appears to be an adaptive change in vitamin A-deficiency which decreases the intestinal cell population.
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PMID:Effect of vitamin A deficiency on rat intestinal digestive & absorptive functions. 253 19

Influence of vitamin A deficiency on ATPase activity in erythrocytes was studied experimentally. It was shown that activity of Mg2+, Na+, K+-ATPase increased, while that of Na+, K+-ATPase decreased under such conditions. The assay of K+ and Na+ in erythrocytes and plasma revealed diminished K+ content in erythrocytes and its elevated level in plasma, Na+ concentration in erythrocytes rose. The author considers that disorders of protein biosynthesis (at the level of translation) in hypovitaminosis A are responsible for the results obtained.
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PMID:[Effect of vitamin A deficiency on ATPase activity and the transport functions of erythrocyte membranes]. 296 91

In spite of the fact that vitamin A exerts an obvious effect on cell membrane permeability, the specific mechanisms of vitamin A participation in stabilizing the cell membrane remain unclear. Therefore studies on the effect vitamin A produces on the main and reserve pathways of the synthesis of adenylnucleotides are of great importance. The experiments on Wistar rats showed that under vitamin A deficiency the content of ATP and ADP in red cells dramatically changed as compared to that in control animals. The ADP content rose by 28% while ATP content dropped down by 33%. Following 14C-adenine administration to the test animals, the label incorporation rate into ADP increased and that into ATP declined. Investigations of the variations produced led to revealing an increase in the activity of phosphatases: Mg2+, Na+, K+-ATPase, K+, Na+-ATPase, Mg2-ATPase.
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PMID:[State of the reserve pathway of adenine nucleotide synthesis in the erythrocytes of white rats with vitamin A deficiency]. 644 29