Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.1.3 (
ATPase
)
65,361
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In 10 southern Indian patients with
tropical sprue
, in vivo dialysis showed a defect of absorption of water and sodium from the rectum, when compared with 11 healthy volunteers. Sodium-potassium-
ATPase
activity, measured in homogenates of rectal biopsies, was significantly diminished in patients with sprue. Magnesium-ATPase and alkaline phosphatase were normal in biopsy homogenates. Decreased activity of colonic sodium-potassium-
ATPase
may contribute to diarrhoea in some patients with
tropical sprue
.
...
PMID:Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue. 284 Mar 63
Faecal excretion of fatty acids is increased in patients with
tropical sprue
because of unabsorbed dietary fatty acids. The excretion of fatty acids correlates well with faecal wet weight. In vitro unsaturated fatty acids inhibited Na K-
ATPase
and Mg-
ATPase
isolated from basolateral membranes of enterocytes and colonocytes. These findings are a possible explanation for the observed abnormalities in water and electrolyte absorption by the colon in patients with
tropical sprue
and steatorrhoea.
...
PMID:Faecal free fatty acids in tropical sprue and their possible role in the production of diarrhoea by inhibition of ATPases. 621 25
