Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.6.1.3 (ATPase)
 65,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Activity of ATPases was studied in erythrocytes of patients with phobia neurosis of the 11 degree and in erythrocytes of mentally healthy patients. The total Mg2+, Na+, K+-dependent ATPase activity of patients with the neurosis was unaltered in blood. But the Mg2+-ATPase activity was increased and the Na+, K+-ATPase activity was decreased in the patients as compared with the control group. Addition of lithium carbonate into incubation mixtures exhibited different effect on the Na+, K+-stimulated ATPase depending upon the initial activity of the enzyme. In blood of patients with low initial values of the enzymatic activity it was increased. But the Na+, K+-ATPase activity was decreased by lithium carbonate in those cases when the initial enzymatic activity was high. Quantitatively the effect of lithium on the enzymatic activity was similar in the both groups of neurotic patients studied (although the direction of changes was oposite).
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PMID:[Activity of Mg 2+, Na+ and K+ stimulated ATPase in erythrocytes of patients with phobic neurosis and the effect of lithium carbonate on the enzymatic activity]. 12 54

In experiments on dogs with local neurosis-continuous flexion of the foreleg-changes were revealed in the beta-rhythm amplitude and the frequency of mean unit activity in the motor cortex, and the appearance and increased amplitude of the theta-rhythm in the hippocampus. Specific activity of Na+-K+-activated, and Mg2+-dependent ATPase decreases in subcortical fractions of the experimental animals' cerebral cortex by 55.0% in the synaptic membranes and 2 to 2.5 times in light and heavy synaptosomes, respectively. In similar fractions of the dorsal hippocampus, the activity of the enzyme decreases by 30.0% in the synaptic membranes and increases by 16.6% in the light synaptosomes and by 6.6% in the heavy ones.
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PMID:[Subcellular changes in the cortex of the motor analyzer and hippocampus of dogs with locally manifested neuroses]. 611 23

A study was made of the changes in synaptosomal membranes and in some synaptic processes under the development of experimental neurosis in rats. Neurotic rats demonstrated changes in the protein/lipid correlation and in the interaction of the fluorescent ANS probe and synaptosomal membranes. This can be accounted for by an increase in the membrane water repellency. The activity of Na, K-ATPase remains unchanged. The rate of noradrenaline, serotonin, dopamine and GABA synaptosomal reverse uptake in neurotic rats was found to be increased.
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PMID:[Changes in the synaptosomal membranes in the chronic neurotization of rats]. 614 68

Experiments were made to study the effect of the animals' neurosis status on the synthesis of macroergs according to the oxidative phosphorylation data and macroerg utilization via the ATPase system. It was demonstrated that in the stage of metabolic deadaptation , neurosis leads to dramatic inhibition of oxidative phosphorylation and its dissociation, decreases the content of macroergs , discoordinates the ATPase system. The prophylactic administration of nicotinic acid derivatives stimulated oxidative phosphorylation, making return to normal the content of macroergs and the ATPase activity. According to some data, the action of chlorodiazepoxide aggravated adverse effects of neurosis. The possibility of correcting brain bioenergetics with nicotinic acid derivatives has been shown.
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PMID:[Possibility of correcting brain bioenergetics in neuroses using nicotinic acid derivatives]. 623 62

The effects of cachexia on the neuromuscular system were investigated in ten young women with anorexia nervosa and in two patients with hysteric neurosis. Ten women, matched for age and height, served as controls. A neurologic examination was performed on all subjects and sensory and motor neurographic recordings were carried out in the upper and lower limbs. Biopsies from the vastus lateralis muscle were stained for myofibrillar ATPase activity and the size and distribution of both histochemical fiber types (types 1 and 2) were determined. Both types of muscle fibers were found to be significantly reduced in size in the cachectic patients but there was a predominant affection of the type 2 fibers. The average numerical distribution of fiber types was almost identical in the two groups. By subjective evaluation, four of the cachectic patients revealed small groups of angulated atrophic fibers, resembling denervation atrophy. Fiber necroses and other myopathic changes were not seen. Although the nerve conduction velocities (NCV) were within normal range in all cases, the motor NCV was generally slower in the cachectic patients than in the controls. The sensory NCV, on the other hand, was almost identical in the two groups. Five of the patients with anorexia nervosa and both cases with hysteric neurosis had clinical signs of a very mild sensory polyneuropathy. These seven cases had a lower body-mass index than the others and both types of muscle fibers and muscle responses were somewhat smaller in these cases. The sensory NCV did not differ from those of the other patients.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The neuromuscular system in patients with anorexia nervosa: electrophysiological and histologic studies. 649 99

Experiments were made to correlate changes in bioelectrical activity of the brain of different animals (rats, cats, monkeys) with neurosis and its treatment to the time course of the activity of ATPase, one of the most important enzymes of energy metabolism. It was demonstrated that the electroencephalogram (EEG) taken during neurosis is marked by an increase in the total energy of quick-wave components and reduction in the total energy of slow-wave ones in all the structures under study, by the deterioration of the rhythm change response. These changes corresponded with the inhibited activity of brain Na, K-ATPase, particularly of Mg-ATPase. The EEG returned to normal and ATPases were activated after nikogamol injections.
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PMID:[Electroencephalogram changes in animals with neurosis as a correlate of metabolic brain disorders]. 653 36