Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.1.3 (
ATPase
)
65,361
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Calcium (Ca
2+
) homeostasis is a critical determinant of cellular function and survival. Endoplasmic reticulum (ER) acts as the largest intracellular Ca
2+
store that maintains Ca
2+
homeostasis through ER Ca
2+
uptake pump, sarco/ER-Ca
2+
ATPase
(SERCA), ER Ca
2+
release channels, inositol 1,4,5-trisphosphate receptor channel (IP
3
R) and ryanodine receptor (RyR), and Ca
2+
-binding proteins inside the ER lumen. Alterations in ER homeostasis triggers ER Ca
2+
depletion and ER stress, which is associated with development of a variety of diseases. In addition, recent studies have highlighted the role of ER Ca
2+
imbalance caused by dysfunction of SERCA, RyR and IP
3
R in various kidney diseases. Despite the progress in understanding the importance of these ER Ca
2+
channels, pumps and binding proteins in the pathogenesis of kidney disease, the treatment is still lacking. In this mini review, we will focus on: (1) Ca
2+
homeostasis in the ER, (2) ER Ca
2+
dyshomeostasis and apoptosis and (3) altered ER Ca
2+
homeostasis in kidney disease, including podocytopathy,
diabetic nephropathy
, albuminuria, autosomal dominant polycystic kidney disease, and ischemia/reperfusion-induced acute kidney injury.
...
PMID:Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease: Pathogenesis and Therapeutic Targets. 3324 15
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