Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.1.25 (triphosphatase)
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Human Gene/Protein
EH domain containing 2 14.3
YSA1H 13.3
histidine triad nucleotide binding protein 3 13.3
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 13.3
WDR75 13.3
CYTH3 13.3
RNA (guanine-7-) methyltransferase 13.3
Src homology 3 domain-containing guanine nucleotide exchange factor 13.3
EFA6R 12.8
Borg5 12.8
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 12.8
BORG4 12.8
NUBP1 12.8
HCA67 12.8
PARIS-1 protein 12.8
SH3 domain-binding protein 4 12.8
C6orf203 12.3
GPR137B 12.3
DIPP2 12.3
thiamine triphosphatase 12.3
EH domain-binding protein 1 12.2
ARF1 GAP 12.0
CPNE6 12.0
Ras homolog gene family, member C 12.0
GTase 11.9
PIR1 11.8
FHOD2 11.8
RGS-PX1 11.8
POLR2C 11.8
TBC1D14 11.8
hSPT5 11.8
RHOBTB1 11.8
CCDC85A 11.8
ADP-ribosylation factor-related protein 1 11.8
CLEC14A 11.6
ADP-ribosylation factor-like 2 11.5
Rho-related BTB domain-containing protein 3 11.5
CD39L2 11.5
Intersectin 2 11.5
ELMOD1 11.5
NUBP2 11.5
syntaxin 10 11.3
LRRC7 11.3
CD39L1 11.2
CFD1 11.2
RTKN2 11.2
Cortactin-binding protein 2 11.2
CD39L3 11.0
DABP 11.0
TBC1D10A 10.9
growth-regulating protein 10.9
RRAGA 10.9
RAB35 10.9
RAB32 10.9
PLEKHM2 10.9
Use1 10.9
ARL8 10.9
sec23 10.8
NTPDase8 10.8
GA protein 10.8
ArhGAP15 10.6
MTG1 10.6
SLAT 10.6
CRAG 10.6
D-AKAP2 10.6
hMet 10.6
budding uninhibited by benzimidazoles 1 10.5
Ral guanine nucleotide exchange factor 10.5
MICAL-L2 10.5
SH3BP1 10.5
RIC3 10.5
ectonucleoside triphosphate diphosphohydrolase 5 10.4
MyoGEF 10.4
protein tyrosine phosphatase receptor type D 10.4
C12orf65 10.4
Mitotic centromere-associated kinesin 10.4
oxysterol-binding protein-related protein 10.3
E-type ATPase 10.3
paracingulin 10.3
RGS12 10.3
SGEF 10.3
CES5 10.3
RHOJ 10.3
EHBP1 10.3
EIF4A2 10.2
AFG3 10.2
regulator of G protein signaling protein 10.2
LRG-47 10.2
WDR41 10.1
Seh1 10.1
RAB13 10.1
STX6 10.1
Cdc42 GTPase-activating protein 10.1
TRIP-1 10.0
DHX29 10.0
DFNA1 10.0
PPP2CB 10.0
semaphorin 3E 10.0
RPGR protein 10.0
KCTD10 10.0
Par1b 10.0
LMTK3 10.0
NTPase 9.9
YAP65 9.9
ACBD3 9.9
phosducin-like 9.9
guanine nucleotide exchange factor for Rap1 9.8
N-ras protein 9.8
ITPase 9.8
p126 9.8
TLN 9.8
brefeldin A-inhibited 9.8
ITSN 9.8
mRNA decapping enzyme 9.8
RAB38 9.8
GCC185 9.8
CHN1 9.8
CTL1 9.7
ARAP3 9.7
MYO9B 9.7
MTH1 9.7
TANGO1 9.7
IRG1 9.6
ARAP1 9.6
RAB39B 9.6
PKN2 9.6
RagD 9.6
RagC 9.6
SLC38A9 9.5
sedlin 9.5
Vti1a 9.5
polo-like kinase 2 9.5
septin 4 9.5
FBLN5 9.5
adenylate cyclase 3 9.4
ARHGAP18 9.4
ecto-ATPase 9.4
RGS18 9.4
RAB23 9.4
RINT-1 9.4
p101 9.4
TAGAP 9.3
ATG101 9.3
Nanog homeobox 9.3
adenylate kinase 2 9.3
ARHGAP21 9.3
ARHGDIB 9.3
WNK2 9.3
p21-activated kinase 3 9.3
dynamin 1 9.3
GC kinase 9.3
Plexin-B1 9.2
SEPT4 9.2
tescalcin 9.2
UDPase 9.2
RGS6 9.2
MIG-2 9.2
Grp1 9.2
Succinic dehydrogenase 9.2
OPA1 protein 9.2
more...
Disease
Morris Hepatoma 9.6
XRN 9.4
Rinderpest 9.0
cHL 9.0
GCS1 8.8
Carpenter syndrome 8.6
Neovascular age-related macular degeneration 8.3
audiogenic epilepsy 8.3
HPC1 8.3
cardiofaciocutaneous syndrome 8.0
NS3 7.9
OPA1 7.8
HOPS 7.6
Costello syndrome 7.1
Shope fibroma 7.1
RGS 7.1
RAT 7.1
audiogenic seizure 7.0
Aeromonas hydrophila infection 7.0
CGD 6.5
AD1 6.5
Degos 6.3
vaccinia 6.2
megakaryocytic leukemia 6.2
BEN 6.1
chondrolysis 6.0
spondyloepiphyseal dysplasia 6.0
PBD 6.0
idiopathic thrombocytopenic purpura 6.0
West Nile Virus 5.9
Liver regeneration 5.8
Fallopian tube 5.8
Sutton 5.8
thyroid adenoma 5.7
Hereditary spastic paraplegia 5.7
Kartagener's syndrome 5.7
Sander 5.7
Lesch-Nyhan syndrome 5.6
Recklinghausen 5.6
Pleomorphic adenoma 5.6
dumping syndrome 5.6
MEN 2B 5.5
hairy leukoplakia 5.5
benign nevi 5.5
HPC 5.5
myeloblastosis 5.4
TTP 5.4
amebic colitis 5.4
Joubert syndrome 5.4
Classical swine fever 5.3
optic atrophy 5.2
Zinc deficiency 5.2
PPP 5.2
Ductal 5.1
African swine fever 5.1
Japanese encephalitis 5.0
neurofibromatosis type 1 4.9
inflammatory breast cancer 4.9
cutis laxa 4.9
Crouzon syndrome 4.9
dengue 4.9
TTP 4.9
Lennox-Gastaut syndrome 4.8
Apert syndrome 4.8
BCH 4.8
COL2A1 4.8
molluscum contagiosum 4.8
lipid disorder 4.7
Small cell carcinoma 4.7
Lennox-Gastaut syndrome 4.6
NS2 4.6
magnesium deficiency 4.6
Hypertrophic 4.6
Hermansky-Pudlak syndrome 4.6
HCI 4.6
viral diarrhea 4.5
hepatitis C 4.5
Hypertrophic cardiomyopathy 4.5
self-injurious behavior 4.4
Cholangiocarcinoma 4.4
PTP 4.4
Bowen's disease 4.4
legionellosis 4.4
Anisakis 4.4
protein deficiency 4.3
acute pulmonary edema 4.3
Roth 4.3
Venezuelan equine encephalitis 4.3
Moore 4.2
hereditary spherocytosis 4.2
Legionella 4.2
Colon cancer 4.2
neurofibromatosis 4.2
yellow fever 4.1
thiamine deficiency 4.1
metachromatic leukodystrophy 4.0
PIN 4.0
adenomyosis 3.9
chemical carcinogenesis 3.9
retinopathy of prematurity 3.9
MMA 3.9
spastic paraplegia 3.8
Human immunodeficiency virus type 3.8
Mitchell 3.8
renal cyst 3.8
pertussis 3.8
hepatitis E 3.8
lymphangioleiomyomatosis 3.7
uveal melanoma 3.7
Recruitment 3.7
macrocephaly 3.7
tonsillitis 3.7
Wells 3.7
SMS 3.7
desmoid 3.6
craniosynostosis 3.6
stomatitis 3.6
FBS 3.5
familial Mediterranean fever 3.5
Sarcoma 3.5
Sarcoma 3.5
skin tumor 3.5
tuberous sclerosis 3.5
Dissociation 3.5
epithelial tumor 3.4
Robinson 3.4
subacute sclerosing panencephalitis 3.3
EBV infection 3.3
bronchiectasis 3.2
Wiskott-Aldrich syndrome 3.2
keratosis 3.2
proliferative diabetic retinopathy 3.2
chikungunya 3.2
PIN 3.2
MAS 3.2
polycystic kidney 3.1
Yersinia 3.1
ovarian cysts 3.1
pseudotuberculosis 3.1
PDE 3.0
CNS diseases 3.0
disorientation 3.0
retinitis pigmentosa 3.0
narcolepsy 3.0
dyskinesia 3.0
chronic granulomatous disease 3.0
hairy cell leukemia 3.0
Chagas 2.9
gastroenteritis 2.9
pancreatic cancer 2.8
ARF 2.8
carcinogenesis 2.8
Mycoplasma 2.8
Charcot-Marie-Tooth disease 2.8
sinusitis 2.8
Graves' disease 2.8
Shigella flexneri 2.8
hypercholesterolemia 2.8
AAA 2.8
BLM 2.8
more...
Symptom
male subfertility 6.3
rundown 5.4
fasciculation 4.0
menopausal symptoms 3.7
twitching 3.3
masculinization 3.0
starvation 2.7
cachexia 1.9
hypotonia 1.8
flushing 1.7
spasticity 1.7
collapse 1.5
spasm 1.5
dystonia 1.3
splenomegaly 1.1
anorexia 0.6
acidity 0.5
ataxia 0.4
seizures 0.4
hypothermia 0.3
angina -0.0
fatigue -0.3
weakness -0.9
anesthesia -1.4
pain -2.6
Drug
Sinefungin 8.6
Coal tar 8.4
Domin 7.9
Mizoribine 7.7
Hydergine 7.5
Carbidopa 7.0
Malachite Green 6.9
Spiegel 6.5
RAL 6.4
Pyridoxal 6.3
Alanine 6.1
Methylprednisolone 5.5
Papaverine 5.5
Sinemet 5.3
Ouabain 5.1
Pravastatin 4.7
Adenosine triphosphate 4.5
DFP 4.5
Parkin 4.5
Parkin 4.5
Isoniazid 4.4
CDP 4.2
Vitamin B 4.1
ZnCl2 4.0
ZnCl2 4.0
Lovastatin 4.0
BLM 3.9
Glycyrrhiza 3.9
IFN-beta 3.8
Amiloride 3.8
Acacia 3.7
Simvastatin 3.7
Amiloride 3.5
-deoxyadenosine 3.3
NAG 3.3
NADH 3.2
G418 3.2
Herceptin 3.2
Fragment 3.2
Asn 3.2
TAT 3.1
ETS 3.0
ICI 3.0
Ringer's solution 2.9
lysine 2.8
CaCl2 2.7
CaCl2 2.7
Taxol 2.7
CaCl2 2.7
Gel 2.5
p75 2.4
Spectrum 2.4
Ethanol 2.1
FAD 1.9
Histamine 1.9
Bifidobacterium 1.8
MAP 1.4
Spectrum 1.4
ABC 1.2
citric acid 1.1
ZnO 0.6
vitamin E 0.2
Nephron 0.2
caffeine -0.1
Asthma -0.3
IFN-gamma -0.5
IL-2 -0.5
CSF -0.6
Dermatol -0.7
Enzyme
triphosphatase 14.3
EC 3.6.1.16 14.3
adenylylsulfate-ammonia adenylyltransferase 14.3
EC 3.6.2.1 13.3
EC 3.6.1.28 13.3
EC 3.6.1.29 13.3
nucleoside triphosphate phosphohydrolase 12.3
EC 3.6.1.17 11.6
NS protease 11.3
Protein 2 10.9
EC 2.7.4.15 10.9
dGTPase 10.2
Dol-P phosphatase 9.9
Ap4A hydrolase 9.8
dTTPase 9.6
GDPase 9.5
i-AAA protease 9.5
dCTP deaminase 9.2
nicotinamide adenine dinucleotide glycohydrolase 9.0
dCTP deaminase 9.0
ATPase 8.9
m-AAA protease 8.8
ADPase 8.7
beta-glycerophosphatase 8.6
trimetaphosphatase 8.6
poly(A)-specific ribonuclease 8.5
dolichol kinase 8.4
DIPP 8.4
EC 3.6.1.1 8.2
poly(A)-specific ribonuclease 8.0
nucleoside diphosphokinase 8.0
exopolyphosphatase 7.9
gluconate dehydrogenase 7.9
thiamine pyrophosphokinase 7.7
elongation factor (EF) 7.7
glycerol-3-phosphate oxidase 7.7
nucleotidase 7.5
CTD kinase 7.2
5'-nucleotidase 7.2
endonuclease V 7.2
ATP diphosphohydrolase 7.1
poly(A) polymerase 7.0
dCMP deaminase 6.9
glucose-6-phosphatase 6.7
p-nitrophenylphosphatase 6.6
succinic dehydrogenase 6.6
apyrase 6.6
exonuclease I 6.5
proton-translocating ATPase 6.5
acylphosphatase 6.5
histidase 6.5
glycine decarboxylase 6.2
Mg2+-ATPase 6.1
cGMP phosphodiesterase 6.0
callose synthase 6.0
inositol phosphatase 6.0
nitrile hydratase 5.9
deoxyribonuclease 5.8
sphingosine kinase 5.8
deoxyribonuclease 5.8
carboxypeptidase E 5.7
3'-exonuclease 5.7
dUTPase 5.7
NAD glycohydrolase 5.6
venom phosphodiesterase 5.5
adenylate kinase 5.4
3-hydroxy-3-methylglutaryl coenzyme A reductase 5.4
calcium pump 5.4
CNPase 5.3
succinate dehydrogenase 5.3
p80 5.2
myosin ATPase 5.2
pyruvate kinase 5.2
acid phosphatase 5.2
transcriptase 5.0
polynucleotide kinase 5.0
3-hydroxyacyl-CoA dehydrogenase 4.9
phosphatidylinositol 4-kinase 4.9
3-hydroxyacyl-CoA dehydrogenase 4.9
cholesterol oxidase 4.9
deoxycytidine kinase 4.9
transhydrogenase 4.9
purine nucleoside phosphorylase 4.9
glucokinase 4.9
transpeptidase 4.8
alanine aminopeptidase 4.8
phosphoinositide 3-kinase 4.8
phospholipase D 4.8
lactic acid dehydrogenase 4.8
RNA polymerase 4.7
gamma-glutamyl transpeptidase 4.7
arginine deiminase 4.6
subtilisin 4.6
MEKK1 4.5
adenosine kinase 4.5
thermolysin 4.5
adenylate cyclase 4.4
glucose-6-phosphate dehydrogenase 4.4
isocitrate lyase 4.4
phytase 4.4
phytase 4.4
kinesin 4.4
protein phosphatase 2A 4.4
PTPase 4.4
ADP-ribosyltransferase 4.4
NADPH oxidase 4.3
ADP-ribosyltransferase 4.3
DNase 4.3
fumarase 4.2
NADPH oxidase 4.2
malate dehydrogenase 4.2
ATP synthase 4.1
diaphorase 4.1
uricase 4.1
xanthine dehydrogenase 4.1
cellulose synthase 4.0
CPR 4.0
hexokinase 4.0
phosphodiesterase 4.0
phosphatidylinositol 3-kinase 3.9
6-phosphogluconate dehydrogenase 3.8
6-phosphogluconate dehydrogenase 3.8
TOR 3.8
citrate synthase 3.8
protein kinase 3.7
ricin 3.7
transglutaminase 3.7
phospholipase C 3.6
guanylate cyclase 3.6
DNA polymerase 3.6
phosphoenolpyruvate carboxylase 3.6
glycerol-3-phosphate dehydrogenase 3.6
cytochrome oxidase 3.6
cathepsin G 3.5
glycerol-3-phosphate dehydrogenase 3.5
cathepsin K 3.5
MPP 3.5
TdT 3.5
beta-glucuronidase 3.4
phosphofructokinase 3.4
cathepsin D 3.3
NADH dehydrogenase 3.3
glutamate dehydrogenase 3.3
phosphoglycerate kinase 3.3
glutamate dehydrogenase 3.2
ribonuclease 3.2
ribonuclease 3.2
matrix metalloproteinase 9 3.2
CAD 3.2
glutamate dehydrogenase 3.2
PDK1 3.2
caspase-8 3.2
TAT 3.1
alkaline phosphatase 3.1
histidine kinase 3.1
mitogen-activated protein kinase 3.1
deaminase 3.0
lactate dehydrogenase 3.0
myosin light chain kinase 2.9
RNase 2.9
more...
Compound
3-hydroxybenzonitrile 12.3
Chlormerodrin 12.0
GppppG 11.5
Deoxyuridine 11.2
Kirromycin 10.8
Purine riboside 10.5
Thiamine triphosphate 10.0
Thiamine triphosphate 10.0
benzyl thiocyanate 9.6
Methapyrilene 9.0
dIMP 9.0
Pinitol 8.6
Thiostrepton 8.5
dITP 8.4
GAP 8.4
Azocoll 8.2
Adenosine 8.2
Adenine arabinoside 8.1
XTP 8.0
dGTP 8.0
Etorphine 7.9
ITP 7.8
dCDP 7.7
Sodium deoxycholate 7.7
Resazurin 7.5
dUDP 7.5
Triphosphate 7.4
dADP 7.4
Pantoprazole 7.2
dATP 7.2
CTP 7.2
Vinyl chloride 7.1
Dolichol 7.1
TTP 7.1
XMP 7.0
UTP 7.0
Fusidic acid 6.9
3'-AMP 6.9
Monocrotaline 6.8
Guo 6.8
7-methylguanosine 6.7
GTP 6.7
P2A 6.7
PPi 6.7
Thiamine 6.7
ribose-5-phosphate 6.7
GMP 6.6
dUMP 6.6
tetraphosphate 6.5
Ara-A 6.4
Rottlerin 6.4
TDP 6.4
dCTP 6.4
Cyproterone acetate 6.4
Rottlerin 6.3
Rottlerin 6.3
Pyridoxal 6.3
Beryllium 6.3
Inosine 6.3
dGMP 6.3
GDP 6.3
Deoxycholic acid 6.2
Cyanogen bromide 6.2
1,2,3,4-tetrahydronaphthalene 6.2
PGA2 6.1
methylguanosine 6.1
Alanine 6.1
Cordycepin 6.1
Cordycepin 6.1
Cordycepin 6.1
IDP 6.1
NEM 6.0
PBD 6.0
Fluvoxamine 5.9
Mg2+ 5.9
Guo 5.9
Rhodopsin 5.9
quinuclidine 5.9
quinuclidine 5.9
Triton WR-1339 5.8
FMLP 5.8
ethanesulfonic acid 5.8
ethanesulfonic acid 5.8
Gold, 5.7
Gold, 5.7
Gold, 5.7
CNA 5.7
TBC 5.7
Methylprednisolone 5.6
HPC 5.6
HPC 5.6
Suramin 5.5
DCC 5.5
Papaverine 5.5
Malachite Green 5.5
3-hydroxyanthranilic acid 5.4
NPP 5.4
Ruthenium red 5.3
Cysteamine 5.3
ADP 5.3
40S 5.2
adenylate 5.2
11-cis-retinal 5.2
Pravastatin 5.2
Camptothecin 5.1
Camptothecin 5.1
Camptothecin 5.1
DBD 5.1
Deoxyribonucleic acid 5.1
dCMP 5.1
Ouabain 5.0
ADP 5.0
ADP 5.0
DEN 5.0
ATP 4.9
Phosphatidylinositol 4.9
DCB 4.9
HPT 4.9
dUTP 4.9
Praziquantel 4.9
Sevoflurane 4.9
glucose-6-phosphate 4.9
Lovastatin 4.9
Guanine 4.9
manganese 4.8
DEP 4.8
isonicotinic acid 4.8
BaCl2 4.8
3-methylhistidine 4.7
Vitamin D3 4.7
CDP 4.7
MgCl2 4.7
NiCl2 4.6
pyridazine 4.6
pyridazine 4.6
Thapsigargin 4.6
Vitamin D3 4.6
MAL 4.5
Elastin 4.5
dimethylarsinic acid 4.5
dimethylarsinic acid 4.5
dimethylarsinic acid 4.5
dimethylarsinic acid 4.5
adenosylmethionine 4.5
dimethylarsinic acid 4.4
DEP 4.4
TCDD 4.4
Paraquat 4.4
Genistein 4.3
uridine 4.3
dimethylarsinic acid 4.3
nicotinamide 4.3
Paraquat 4.2
L-T3 4.2
DNP 4.2
Wortmannin 4.2
TPP 4.2
HCI 4.2
Glycogen 4.1
fMet 4.1
more...