Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.1.25 (triphosphatase)
 1,529 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was made of the activity of nucleoside diphosphatase (NDPase, EC 3.6.1.16) and nucleoside triphosphatase (NTPase, EC 3.6.1.15) that catalyze enzymatic dephosphorylation of UDP, CDP, UTP, and CTP in mitochondria and postmitochondrial supernatant fraction of rat liver 30 min, 1, 3, 6 and 24 h following 60Co-gamma-irradiation with a dose of 774 mC/kg. The observed phase changes in the enzyme activity depended on the times of exposure, a cell fraction, and nucleotides under study. Both uridylic and cytidylic nucleotides exhibited a significant increase in the their enzymatic disintegration being more pronounced at a comparatively later times, that is, 6 h, and particularly, 24 h after irradiation.
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PMID:[Catabolism of pyrimidine nucleotides in the liver of irradiated animals]. 283 67

1. Parotid plasma membrane nonpump low-affinity Ca(2+)-ATPase, which possesses high-affinity (Ca2+ + Mg2+)-ATPase activity, was characterized. 2. Purified Ca(2+)-ATPase hydrolyzed the nucleoside triphosphates, GTP, ITP, CTP, UTP, TTP (67-93% of ATP) and nucleoside diphosphates, ADP, GDP, IDP, CDP, TDP (12-40% of ATP) but not AMP and p-NPP. 3. The maximum activities of Ca(2+)- and (Ca2+ + Mg2+)-ATPases were obtained in the presence of 1 mM and 0.13 microM Ca2+, respectively. 4. The Km values for Ca2+ in Ca(2+)- and (Ca2+ + Mg2+)-ATPases were 0.2 mM and 22 nM, respectively. 5. The activities of both Ca(2+)- and (Ca2+ + Mg2+)-ATPases were found in the right-side-out-vesicles obtained from the plasma membrane-rich fraction. 6. These features suggest that Ca(2+)-ATPase is an ecto-Ca(2+)-dependent nucleoside triphosphatase.
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PMID:The possibility that Ca(2+)-ATPase from the plasma membrane-rich fraction of bovine parotid gland is ecto-Ca(2+)-dependent nucleoside triphosphatase. 806 15