Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.1.25 (
triphosphatase
)
1,529
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Wiskott-Aldrich syndrome
(
WAS
) is an X-linked immunodeficiency disorder associated with lymphocytes and platelet abnormalities. The gene that encodes the
Wiskott-Aldrich
protein (WASP) was recently isolated, and shown to be defective in
WAS
patients. WASP contains multiple domains that interact with various signalling proteins, including the guanine
triphosphatase
(GTPase) Cdc42Hs and SH3 domain-containing proteins. Biochemical and genetic evidence strongly suggests that WASP is an important protein in the regulation of cell morphology. Recent progress in the identification of molecular partners for WASP suggests a molecular mechanism for the cellular abnormalities of
WAS
.
...
PMID:Understanding the molecular basis of Wiskott-Aldrich syndrome. 981 92
