Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.5.4.4 (adenosine deaminase)
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Human Gene/Protein
adenosine deaminase 12.6
mutant adenosine deaminase 12.6
Adenosine deaminase protein 12.6
MHC class I HLA-B 11.6
ADORA2 11.6
ubiquitin-conjugating enzyme E2Q family member 1 11.6
cat eye syndrome chromosome region, candidate 1 11.6
dsRAD 11.6
ADAT1 11.3
CECR1 11.3
ADAL 11.3
RNA editase 11.1
ADAD2 11.0
spermatid perinuclear RNA binding protein 11.0
STRBP 11.0
ring finger protein 126 11.0
dsRNA adenosine deaminase 10.9
Adenosine deaminase 10.8
ADA2 10.8
adenosine kinase 10.8
NICE-3 10.6
ADAR1 10.5
ADAR3 10.3
ADAR2 10.3
nucleoside phosphorylase 10.3
NICE1 10.3
ADAR 10.2
purine nucleoside phosphorylase 10.2
guanine deaminase 10.1
ADARB1 10.1
AMP deaminase 10.1
Na+/H+ exchanger isoform NHE-3 10.0
AIH2 10.0
3',5'-cyclic AMP phosphodiesterase 10.0
NICE-4 10.0
ADORA3 9.9
ADA 9.8
TENR 9.8
phosphoglucomutase 2 9.8
ADAT3 9.8
guanine aminohydrolase 9.8
adenosine deaminase-like 9.8
RNA adenosine deaminase 9.7
AdoHcyase 9.7
splicing factor proline/glutamine-rich 9.6
Ribosomal protein S8 9.6
Kell blood group antigen 9.6
HBGR2 9.6
interleukin 2 receptor gamma chain 9.6
LALP1 9.6
ecto-5'-nucleotidase 9.6
S-adenosylhomocysteine hydrolase 9.5
speriolin 9.4
Na+/nucleoside cotransporter 9.4
Tenr 9.4
POU domain class 5 transcription factor 1 9.4
isoform L 9.4
ADARB2 9.3
S100 calcium binding protein P 9.3
ribosomal protein S26 9.3
interleukin 27 9.3
GluR-B 9.2
adenosine monophosphate deaminase 9.2
Guanine deaminase 9.2
HLA-DRB3*01 9.1
ENPP3 9.1
5'-nucleotidase 9.1
TA5 9.0
GPBP 9.0
FAP protein 9.0
AP-2 gamma 8.9
YF5 8.9
red cone pigment 8.9
DACT3 8.9
S100A7A 8.9
phosphoglucomutase 1 8.9
5' nucleotidase 8.8
DPPIV 8.8
C21orf2 8.8
ARPP 8.8
more...
Disease
Gluthathione synthetase deficiency 12.6
Adenylate kinase deficiency 12.0
ADA-SCID 11.9
ADA deficiency 11.5
Tuberculous empyema 11.0
tuberculous effusion 10.6
tuberculous pleurisy 10.0
CLL variants 10.0
refractory hairy cell leukemia 10.0
Pseudochylothorax 10.0
PNP deficiency 9.8
alymphocytosis 9.8
stage IIIB breast cancer 9.8
Tuberculous meningoencephalitis 9.4
Tuberculous peritonitis 9.3
trisomy 20q 9.1
skin pigmentation disorder 8.9
Primary systemic vasculitis 8.9
congenital hemolytic anemia 8.8
X-linked hypogammaglobulinemia 8.3
secondary antibody deficiency 8.3
hereditary nonspherocytic hemolytic anemia 8.3
L.donovani 8.2
Milwaukee shoulder 8.2
Milwaukee shoulder 8.1
congenital hypoplastic anemia 7.9
Pleural infection 7.9
c-ALL 7.8
Frohlich 7.6
Combined immunodeficiency 7.6
gouty nephropathy 7.5
mouse leukemia L1210 7.4
antibody deficiency syndrome 7.3
Cutaneous polyarteritis nodosa 7.3
X-linked severe combined immunodeficiency 7.2
Hypothalamic hamartoma 7.2
reticular dysgenesis 7.2
prolymphocytic leukemia 7.2
SCID 7.2
Mycobacterium kansasii infection 7.1
Cyclic neutropenia 7.0
pleurisy 7.0
Hers 7.0
hypoplastic anemia 6.9
Pythiosis 6.9
KCS 6.8
erythroblastopenia 6.7
Tuberculous meningitis 6.7
Primary immunodeficiency 6.6
ML III 6.5
malignant pleural effusion 6.5
hairy cell leukemia 6.5
myocardial hypoxia 6.5
B cell neoplasms 6.4
extrapulmonary tuberculosis 6.3
ARTS 6.3
CML progression 6.3
infectious meningitis 6.3
APRT deficiency 6.3
Anaplasmosis 6.3
enzyme deficiency 6.3
immune deficiency 6.3
Lesch-Nyhan syndrome 6.2
Heck's disease 6.2
abdominal cyst 6.2
CPX 6.2
MODY1 6.2
Autoimmune encephalitis 6.0
WDHA syndrome 6.0
MODY 5.9
immunocytoma 5.8
refractory CLL 5.7
hypermethioninemia 5.7
erythroblastosis fetalis 5.7
HOA 5.6
early disease onset 5.5
viral meningitis 5.5
Sneddon's syndrome 5.5
lymphopenia 5.4
polyclonal hypergammaglobulinemia 5.4
more...
Symptom
Livedoid 7.0
bradypnea 5.9
pleuritic chest pain 5.7
livedo 5.2
abdominal fullness 4.9
consciousness disturbance 4.5
non-productive cough 4.5
prostration 4.1
night sweats 4.0
lightheadedness 3.6
POA 3.5
swollen joints 3.5
hyperemesis gravidarum 3.5
Anoxia 3.5
neck stiffness 3.4
leg edema 3.2
clonus 3.1
splenomegaly 2.8
neurological disability 2.7
Hudson 2.5
productive cough 2.5
hypoproteinemia 2.5
functional recovery 2.3
tonic-clonic seizure 2.2
hypercapnia 2.2
nasal discharge 2.2
starvation 2.2
chest pain 2.1
nausea and vomiting 2.0
hypocapnia 1.9
exertional dyspnea 1.9
cough 1.9
hypotonia 1.7
anorexia 1.7
chronic cough 1.6
leg pain 1.6
dyspnea 1.5
Ill 1.5
exhaustion 1.4
nausea 1.4
tachypnea 1.3
hyperoxia 1.2
sore throat 1.2
dystonia 1.1
seizures 1.1
hypothermia 1.1
hoarseness 1.1
vomiting 1.0
spasticity 0.9
dysarthria 0.7
abdominal pain 0.7
apathy 0.6
sleepiness 0.5
chills 0.5
myoclonus 0.5
hepatosplenomegaly 0.5
diarrhea 0.5
acute stress 0.4
headache 0.4
wheezing 0.4
paresthesia 0.3
fatigue 0.3
shortness of breath 0.2
ataxia 0.2
ENT 0.2
lethargy 0.1
hepatomegaly 0.1
hemoptysis 0.0
respiratory distress -0.1
myalgia -0.1
angina -0.2
collapse -0.2
arthralgia -0.2
discomfort -0.3
discomfort -0.4
overweight -0.5
tremor -0.6
syncope -0.6
analgesia -0.6
weakness -0.6
more...
Drug
D-Eritadenine 12.6
Pegademase bovine 12.6
Amdoxovir 11.2
Adenosine deaminase 11.0
Deoxyadenosine 10.7
Nipent 10.5
2'-Deoxyinosine 10.0
Formycin 9.8
Hexobendine 9.4
Acadesine 9.2
-deoxyadenosine 9.0
Ara-A 8.8
Nelarabine 8.6
Formycin B 8.4
Thyrogen 7.6
Propentofylline 7.3
Zinc sulfate 7.1
Zinc sulfate 7.0
Perhexiline 6.7
ddI 6.6
Levamisol 6.5
Rolipram 6.2
Adenosine triphosphate 6.1
Theophylline 6.1
Mizoribine 6.0
Poloxamer 5.9
Isoprinosine 5.8
Fludarabine 5.7
Rhubarb 5.6
PNT 5.5
Clofarabine 5.5
G418 5.5
FSH-beta 5.3
CFX 5.3
SrCl2 5.2
ETS 5.1
Salmon calcitonin 5.1
SrCl2 5.1
Abatacept 5.0
Cilostazol 4.9
Talc 4.9
Forskolin 4.8
Desferal 4.6
Glutamic acid 4.6
Nebivolol 4.5
Desferal 4.5
Rimonabant 4.2
Mycophenolic acid 4.2
Piracetam 4.2
caffeine 4.1
Secretin 4.1
CoCl2 3.9
CoCl2 3.9
Indomethacin 3.9
CTX 3.9
Scopolamine 3.8
Epigallocatechin 3.8
Glycerol 3.7
OMP 3.7
Papaverine 3.7
Emodin 3.7
GRF 3.7
Dihydro 3.6
CTC 3.6
Iloprost 3.6
DMAP 3.5
Emodin 3.4
Tuberculin 3.4
Viagra 3.4
Sulpiride 3.4
RFP 3.4
Glide 3.3
CTC 3.3
Kainic acid 3.3
Rutin 3.2
NH3 3.1
OTC 3.1
PMEA 3.1
Glucagon 3.1
balanced salt solution 3.0
more...
Enzyme
adenosine deaminase 12.6
adenosine deaminase 12.6
inosine nucleosidase 11.6
guanosine deaminase 11.3
deoxyadenosine kinase 11.0
adenine deaminase 10.9
adenosine kinase 10.9
purine nucleoside phosphorylase 10.3
ADPR-PPase 10.3
inosine kinase 10.1
AMP nucleosidase 10.0
AMP deaminase 10.0
guanase 9.8
adenosine nucleosidase 9.8
imidazolonepropionase 9.8
esterase D 9.3
phosphopentomutase 9.3
S-adenosyl-L-homocysteine hydrolase 9.2
5'-nucleotidase 9.1
adenine phosphoribosyltransferase 8.8
nucleotidase 8.5
GMP reductase 8.4
deoxyribose-5-phosphate aldolase 8.4
adenylosuccinate lyase 8.4
L-lysine alpha-oxidase 8.2
deoxycytidine kinase 8.2
aldehyde dehydrogenase 8.0
deoxyguanosine kinase 8.0
xanthine phosphoribosyltransferase 8.0
PRPP synthetase 7.8
adenylate kinase 7.8
AICAR transformylase 7.8
prolinase 7.8
nucleotide pyrophosphatase 7.8
nucleoside phosphotransferase 7.7
penicillopepsin 7.7
phosphoglyceromutase 7.6
5'-methylthioadenosine nucleosidase 7.6
methylthioadenosine phosphorylase 7.5
adenylosuccinate synthetase 7.5
deaminase 7.5
cytidine deaminase 7.4
phosphoglucomutase 7.4
inosine triphosphatase 7.3
IMP cyclohydrolase 7.3
DHOdehase 7.2
dipeptidyl peptidase IV 7.2
apyrase 7.1
gluconate dehydrogenase 7.1
hypoxanthine-guanine phosphoribosyltransferase 7.1
nucleoside hydrolase 7.1
phosphoglycolate phosphatase 7.0
6-phosphogluconate dehydrogenase 7.0
6-phosphogluconate dehydrogenase 7.0
S-adenosylhomocysteine nucleosidase 7.0
uridine kinase 6.9
nucleoside diphosphokinase 6.8
3'-phosphatase 6.8
ribokinase 6.8
dCMP deaminase 6.7
SPT 6.7
protein methylase II 6.7
ribonucleotide reductase 6.6
nucleoside triphosphate phosphohydrolase 6.6
ribonucleotide reductase 6.6
tripeptidase 6.6
xanthine oxidase 6.5
UMP kinase 6.4
carboxypeptidase S 6.4
GMP synthetase 6.4
IMP dehydrogenase 6.4
thymidine phosphorylase 6.3
CMP kinase 6.3
deoxycytidine deaminase 6.2
histidinol dehydrogenase 6.1
D-aspartate oxidase 6.0
mevalonate kinase 6.0
SsuE 6.0
SPT 6.0
phosphoglucose isomerase 6.0
more...
Compound
C11H16N4O4 12.6
2-Azaadenosine 12.6
C11H16N4O4 12.6
2,6-Diaminopurine ribonucleoside 12.6
2-Azaadenine 12.6
Coformycin 12.5
9-Deazaadenosine 11.6
Deoxycoformycin 11.5
5-Iodotubercidin 11.3
5-Iodotubercidin 11.3
5-Iodotubercidin 11.3
5-Iodotubercidin 11.2
Deoxyadenosine 10.8
8-Cyclopentyltheophylline 10.8
2-Methyladenosine 10.6
Substance B 10.6
N6-Benzyladenosine 10.6
N6-Benzyladenosine 10.6
nonyl 10.5
Purine riboside 10.4
6-Methoxypurine 10.3
2-Azahypoxanthine 10.3
1,4-dichloro-2-butyne 10.0
bicyclo[3.1.0]hexan-2-ol 10.0
bicyclo[3.1.0]hexan-2-ol 10.0
1,4-dichloro-2-butyne 10.0
bicyclo[3.1.0]hexan-2-ol 10.0
2-Chloroadenosine 9.9
2-Chloroadenosine 9.9
Stannic chloride 9.8
Stannic chloride 9.8
Stannic chloride 9.8
Neplanocin A 9.7
Formycin A 9.6
PADA 9.6
Ara-G 9.3
Ara-G 9.3
1H-imidazole-4-carboxylic acid 9.3
5'-Deoxyadenosine 9.3
Aristeromycin 9.1
GAH 9.0
C5H5NO 9.0
GMDP 9.0
Inosine 8.9
Deoxyinosine 8.9
C16H14N2O2 8.8
Fludarabine phosphate 8.8
thieno[2,3-c]pyridine 8.8
1,3-cyclopentanedicarboxylic acid 8.8
Adenosine 8.8
Purine nucleoside 8.8
Adenine arabinoside 8.7
NBTGR 8.7
NBTGR 8.7
Sangivamycin 8.7
NBTGR 8.7
NBTGR 8.7
6-Chloropurine 8.6
5-Methyluridine 8.6
N-methyladenine 8.5
dipropyl 8.5
Formycin B 8.4
Sulmazole 8.4
Formycin B 8.4
cyclopentyl 8.3
D-ribose-1-phosphate 8.3
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde 8.3
Ara-A 8.3
Cordycepin 8.3
Cordycepin 8.3
Cordycepin 8.3
ara-AMP 8.3
ara-AMP 8.3
dADP 8.2
Deoxyguanosine 8.2
dATP 8.1
MMPR 8.0
C5H8 8.0
Purine 8.0
Homocysteine thiolactone 8.0
more...