Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Media supplemented with purine (7H-imidazo[4,5-d]pyrimidine) or the purine analogue 2,6-diaminopurine (DAP) can be employed to select several classes of purine-resistant variants from mutagenized cultures of Drosophila. One class results in elevated resistance to purine and diaminopurine which is correlated with elevated activity of the enzyme
adenosine deaminase
(
adenosine aminohydrolase
=
EC 3.5.4.4
). The first member of this class,
Pur
R, maps to position 82 +/- in the right arm of the second chromosome. The
Pur
R mutation causes an elevation of
adenosine deaminase
(
ADA
) enzyme activity, apparently by altering a thermolabile,
ADA
-specific repressor.
Pur
R may thus encode a negative regulator of
adenosine deaminase
activity similar to the
ADA
-binding protein found in mammalian systems.
...
PMID:The PurR mutation of Drosophila melanogaster confers resistance to purine and 2,6-diaminopurine by elevating adenosine deaminase activity. 210 78
