Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.5.4.4 (adenosine deaminase)
 5,136 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Attempts to identify mechanisms by which calcium antagonists might influence intracellular metabolism have not yet yielded conclusive findings. In this study bepridil, verapamil, nifedipine, and nisoldipine were found to have no influence on the rate of rat heart myosin adenosine triphosphatase or the calcium dependence of myofibrillar adenosine triphosphatase. None of these calcium antagonists alters the rate of reaction of any of the adenine nucleotide catabolic or adenosine salvage enzymes, adenylate kinase, creatine kinase, adenosine kinase, adenosine deaminase, or 5' nucleotidase, in extracts of rat heart. All four compounds, however, reduced, apparently in a non-specific manner, the rate of uptake of adenosine by myocytes isolated from rat heart. It is concluded that calcium antagonists may, through intercalation with the sarcolemmal membrane, inhibit efflux of adenosine formed by catabolism of adenine nucleotides in ischaemic myocytes. This might offer therapeutic advantage since the intracellular concentration of adenosine would thereby be increased, allowing an increased rate of incorporation of adenosine into the adenosine triphosphate pool in reoxygenated myocardium.
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PMID:Calcium antagonists and adenine nucleotide metabolism in rat heart. 349 85

Effects of adriamycin (ADM) treatment on rat heart cells in culture were examined. ADM treatment (lug/ml) for 3 hr, 48 to 51hr of culture age, had no effect on oxygen consumption, myosin content or myosin ATPase activity. In contrast, the activities of creatine kinase, adenylate kinase and adenosine deaminase were significantly lower in ADM-treated cells than in corresponding controls at 72 and 96 hr of culture age. Fall in the activities of these key enzymes of adenine nucleotide metabolism would lead to disturbances in energy metabolism, and results in the functional impairment of heart cells.
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PMID:Effects of adriamycin on enzymes of adenine nucleotide metabolism in heart cell cultures. 408 19