Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) is a water-soluble organogermanium compound that exerts various physiological effects, including anti-inflammatory activity and pain relief. In water, Ge-132 is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (
THGP
), which in turn is capable of interacting with cis-diol compounds through its trihydroxy group, indicating that this compound could also interact with diol-containing nucleic acid constituents. In this study, we evaluated the ability of
THGP
to interact with nucleosides or nucleotides via nuclear magnetic resonance (NMR) analysis. In addition, we evaluated the effect of added
THGP
on the enzymatic activity of
adenosine deaminase
(
ADA
) when using adenosine or 2'-deoxyadenosine as a substrate. In solution,
THGP
indeed formed complexes with nucleotides or nucleosides through their cis-diol group. Moreover, the ability of
THGP
to form complexes with nucleotides was influenced by the number of phosphate groups present on the ribose moiety. Notably,
THGP
also inhibited the catalysis of adenosine by
ADA
in a concentration-dependent manner. Thus, interactions between
THGP
and important biological nucleic acid constituents might be implicated in the physiological effects of Ge-132.
...
PMID:The Organogermanium Compound Ge-132 Interacts with Nucleic Acid Components and Inhibits the Catalysis of Adenosine Substrate by Adenosine Deaminase. 2842 85
