Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adenosine increases the activity of
tyrosine 3-monooxygenase
in intact pheochromocytoma cells. The effect of adenosine is not dependent upon extracellular Ca2+, and is not accompanied by an increase in catecholamine secretion from the cells. Adenosine deaminase decreases the basal activity of
tyrosine 3-monooxygenase
, and almost completely abolishes the activation of this enzyme by adenosine. In cells treated with
adenosine deaminase
, 2-chloroadenosine causes a 2- to 5-fold increase in
tyrosine 3-monooxygenase
activity. 2-Chloroadenosine produces half-maximal activation at a concentration of 0.1 microM, and maximal activation at 10 microM. Incubation of cells with 2-chloroadenosine produces a stable activation of
tyrosine 3-monooxygenase
, as measured in vitro. Finally, 3-chloroadenosine increases the content of cAMP in pheochromocytoma cells, and increases the incorporation of 3H into cAMP in cells that have been preincubated with [3H]adenine. This rise in cAMP presumably mediates the activation of
tyrosine 3-monooxygenase
by 2-chloroadenosine. Adenosine appears to be an endogenous regulator of
tyrosine 3-monooxygenase
activity in pheochromocytoma cells.
...
PMID:Activation of tyrosine 3-monooxygenase in pheochromocytoma cells by adenosine. 610 63
