Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present study was designed to determine whether endogenous and exogenous adenosine modulates endothelin (ET)-induced bronchoconstriction. Exogenous adenosine enhances ET-induced bronchoconstriction. Following pretreatment with
adenosine deaminase
and theophylline to eliminate or antagonize endogenous adenosine,
ET-1
-induced bronchoconstriction was significantly attenuated, but not that of ET-3. In conclusion, this is the first report of an enhancement of ET-induced bronchoconstriction of guinea pig airways by endogenous and exogenous adenosine. Our findings may be useful in designing specific adenosine receptor antagonists as therapeutic agents in the management of bronchial asthma.
...
PMID:Adenosine modulates endothelin-induced bronchoconstriction in guinea pig airway. 898 Apr 68
We examined the effect of
ET-1
on cyclic AMP levels in rat cerebral cortex. The peptide caused a concentration-dependent increase of [(3)H]cyclic AMP accumulation after 10 min of treatment. This effect was due to adenosine accumulation since it was inhibited by the treatment with
adenosine deaminase
.
ET-1
, apart from being able to increase cyclic AMP, also potentiated the cyclic AMP generated by isoprenaline in the presence of
adenosine deaminase
. Experiments performed in the presence of BQ-123 or BQ-788, specific ET(A) or ET(B) receptor antagonists respectively indicated that ET(B) was the receptor involved. This effect was dependent on extracellular and intracellular calcium concentration. These findings suggest that
ET-1
plays a modulatory role in cyclic AMP generation systems in cerebral cortex.
...
PMID:Endothelin-1 increases isoprenaline-enhanced cyclic AMP levels in cerebral cortex. 1070 51
