Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.5.4.4 (adenosine deaminase)
 5,136 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Liposomes of different composition and N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine (GMPD) encapsulated in them are studied for their effect on the functional activity of macrophages by means of determining the 5'-nucleotidase and adenosine deaminase activity in the in vivo experiments. It is shown that both liposomes and GMDP encapsulated in them increase the activity of adenoside deaminase and decrease that of 5'-nucleotidase. This evidences for a change in the adenosine metabolism in the alveolar and peritoneal macrophages and an increase in the functional activity of cells which resulted from that rise. The manifestation of the process depends both on the lipid composition of liposomes and their charge. The observed increase in the functional activity of the alveolar macrophages under the effect of liposomes and GMDP encapsulated in them correlates with inhibition of the lung metastases development in mice.
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PMID:[The effect of muramyl dipeptide analog, GMPD, incorporated into liposomes of various composition on the functional activity of macrophages]. 256 Oct 33

The influence of a new, liposome-encapsulated muramyldipeptide analog--GMDP--on Lewis lung carcinoma spreading was studied in mice in which primary tumor had been removed. The drug was found to significantly decrease the extent and number of lung metastases, as compared to mice which had not received GMDP. This was matched by recovery of alveolar and splenic macrophages functional activity, as assessed by adenosine deaminase and 5'-nucleotidase levels in these cells.
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PMID:[Antimetastatic effect of a liposome-enclosed analog of muramyl dipeptide]. 283 5

N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine (GMDP), a new liposome-encapsulated muramyl dipeptide analog, was studied for its effect on the Lewis lung carcinoma metastatic spreading as well as on the adenosine deaminase (ADA) and 5'-nucleotidase (5-N) activity in the alveolar and peritoneal mice macrophages. The drug administration was found to cause a sharp dose-dependent decrease in the lung metastases volume and number as compared to those in mice not treated with GMDP. The antimetastatic effect of GMDP is accompanied by an increase in the functional macrophage activity determined by ADA and 5-N level in these cells.
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PMID:[Effect of GMDP encapsulated into liposomes on metastatic spread of Lewis lung carcinoma]. 285 Jan 49

It has been established that N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine (GMDP), a new synthetic analog of muramyl dipeptide, while incubated in vitro with macrophages essentially inhibits 5'-nucleotidase (5-N) activity without any influence on the activity of adenosine deaminase in these cells. The maximal effect was recorded 24 h after co-incubation. As 0.01 = 1 microgram/ml concentration of GMDP was added, the enzyme activity gradually decreased to minimum. L-D-isomer of GMDP was shown to affect 5-N activity whereas the effect of its analog with a double peptide chain GM (DP)2 was found to be less. Inhibition of 5-N activity may be one of the mechanisms by which macrophages are activated under the influence of GMDP.
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PMID:[Changes in purine metabolism in the macrophages of mice exposed to a new synthetic analog of muramyl dipeptide]. 299 Jun 3