Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
1. Extracellular degradation of adenosine by
adenosine deaminase
was studied in the rat duodenum using high performance liquid chromatography (HPLC) and pharmacological techniques. 2.
Relaxant
responses to adenosine (1-10 microM) were potentiated in a concentration-dependent manner by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and deoxycoformycin, both of which are inhibitors of
adenosine deaminase
. 3. Breakdown of adenosine, determined by HPLC, due to incubation with segments of rat duodenum was inhibited by both EHNA and deoxycoformycin. Cytosolic sources of
adenosine deaminase
were excluded. 4.
Relaxant
responses to adenosine were also potentiated by the adenosine transport inhibitor dilazep, which did not inhibit
adenosine deaminase
activity. 5. The extracellular
adenosine deaminase
activity (4 units/g tissue) was high compared with activity previously determined in other organs.
...
PMID:Degradation of adenosine by extracellular adenosine deaminase in the rat duodenum. 326 22
