Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The genes for
adenosine deaminase
(
ADA
) and S-adenosyl homocysteine hydrolase (
AHCY
or SAHH) are known to be syntenic and within measurable distance from each other, on chromosome 20 in man. In the present study an informative family is described in which the recombination fraction (theta) between the respective genes is estimated to be about 0.18. Together with the published finding of theta = 0.15 (Eiberg and Mohr 1985) in informative Danish families, the recombination fraction for the pooled data is calculated to be theta = 0.14 (in men), theta = 0.08 (in women) and theta = 0.13 (both sexes taken together).
...
PMID:Linkage relationship between the genes for adenosine deaminase and S-adenosyl-homocysteine hydrolase on human chromosome 20. 367 11
The gene loci for S-adenosylhomocysteine hydrolase (
AHCY
) and
adenosine deaminase
(
ADA
), two enzymes with related metabolic functions, have both been assigned to human chromosome 20. We have used rodent-human somatic hybrids containing translocations involving human chromosome 20 to more precisely determine the relative locations of the
AHCY
and
ADA
loci. Our results assign the
AHCY
locus to the long arm of chromosome 20, in the region cen---- q131 , and
ADA
to the region q131 ----qter.
...
PMID:Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen----q131) and adenosine deaminase (q131----qter) on chromosome 20. 658 34
