Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tuberculostearic acid
(
TSA
) is known to be one of the characteristic lipid in the limited species of the order Actinomycetale, including Mycobacterium tuberculosis. We studied the significance of detecting
TSA
in the diagnosis of tuberculosis from clinical specimens collected from 791 patients with various respiratory diseases by using gas--chromatography/mass--spectrometry. By our method, the detectable limit of
TSA
was around 10(2)-10(3) bacilli of Mycobacterium tuberculosis, and our method is as sensitive as culture examination for tuberculosis. In sputa collected from patients with active pulmonary tuberculosis (n=169),
TSA
positively was around 90%, while less than 10% false positive ws also recognized. In pleural effusion (n=81) and bronchial washing (n=91) collected from patients with active tuberculosis, the positivity of
TSA
was around 70%. We could also detect
TSA
in about 30% of clinical specimens collected from patients suspected of tuberculosis. The diagnostic sensitivity of
TSA
for tuberculosis was similar to that of
adenosine deaminase
activity (ADA), while
TSA
was slightly superior to ADA in specificity. These findings indicate that detection of
TSA
from clinical specimens is useful to make rapid diagnosis of pulmonary tuberculosis.
...
PMID:[Basic and clinical evaluation of rapid diagnosis of tuberculosis by detecting tuberculostearic acid]. 231 61
