Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Flavonols like quercetin,
myricetin
, and kaempferol inhibit the activity of the
adenosine deaminase
of endothelial cells (IC50 between 26 and 32 mumol/l), while flavones are inactive. These results support the suggestion that many pharmacological actions of flavonoids are mediated by an amplification of the effect of endogenous adenosine via adenosine receptors because
adenosine deaminase
is responsible for the adenosine inactivation.
...
PMID:Inhibition of adenosine deaminase activity of aortic endothelial cells by selected flavonoids. 872 Mar 82
